In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06

被引：0
|
作者：
Patricia Alves Reis
Karla Ceodaro Pais
Monica Farah Pereira
Bruno Douradinha
Natália Ferreira Costa
Carlos Roland Kaiser
Patricia Torres Bozza
André Luiz Lisboa Areas
Mariano Gustavo Zalis
Marcelle de Lima Ferreira
Marcos Vinícius Nora de Souza
Valber da Silva Frutuoso
Hugo Caire de Castro-Faria-Neto
机构：
[1] Instituto Oswaldo Cruz,Laboratório de Imunofarmacologia
[2] Instituto de Tecnologia em Fármacos (Farmanguinhos),Laboratorio de Infectologia e Parasitologia Molecular, Serviço de Patologia Clínica
[3] Fundação Oswaldo Cruz,undefined
[4] Instituto de Química,undefined
[5] Laboratório de Ressonância Magnética Nuclear,undefined
[6] Unità di Medicina Rigenerativa e Immunologia,undefined
[7] Fondazione Ri.MED c/o IRCCS-ISMETT,undefined
[8] Hospital Universitário Clementino Fraga Filho,undefined
[9] Universidade Federal do Rio de Janeiro,undefined
来源：
Parasitology Research | 2018年 / 117卷
关键词：
Malaria; Antimalarial drug; Chloroquine; Chloroquine resistance;
D O I：
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中图分类号：
学科分类号：
摘要：
Antimalarial interventions mostly rely upon drugs, as chloroquine. However, plasmodial strains resistant to many drugs are constantly reported, leading to an expansion of malaria cases. Novel approaches are required to circumvent the drug resistance issue. Here, we describe the antimalarial potential of the chloroquine analogue 2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]amino] ethanol (PQUI08001/06). We observed that PQUI08001/06 treatment reduces parasitemia of both chloroquine-resistant and -sensitive strains of Plasmodium falciparum in vitro and P. berghei in vivo. Our data suggests that PQUI08001/06 is a potential antimalarial therapeutic alternative approach that could also target chloroquine-resistant plasmodial strains.
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页码：3585 / 3590
页数：5
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