The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine)

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作者
Colin J. Thompson
Caixia Ding
Xiaozhong Qu
Zhenzhong Yang
Ijeoma F. Uchegbu
Laurence Tetley
Woei Ping Cheng
机构
[1] The Robert Gordon University,School of Pharmacy and Life Sciences
[2] Chinese Academy of Sciences,State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry
[3] School of Pharmacy,University of London
[4] University of Glasgow,Integrated Microscopy Facility, Institute of Biomedical and Life Sciences
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Self-assembly; Nanoparticles; Micelle; Amphiphilic polymer;
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摘要
Twelve novel poly(allylamine) (PAA)-based, comb-shaped amphiphilic polymers have been developed. Hydrophobic groups of cetyl, palmitoyl and cholesteryl were randomly grafted to PAA and quaternisation was carried out on some modified polymers. Polymers were characterised using 1H NMR, elemental analysis and differential scanning calorimetry. All polymers formed nano self-assemblies in the aqueous solution with a positive zeta potential and were able to encapsulate a hydrophobic agent, methyl orange, in the core. The critical aggregation concentration (CAC) and the microviscosity were found to be dependent on the polymer hydrophobicity. Being the most hydrophobic polymer, cholesteryl-grafted PAA had the lowest CAC (0.02 mg mL−1) and the highest microviscosity. They appeared to form dense nanoparticles and were transformed into novel nanostructures in the presence of free cholesterol. Palmitoyl-grafted polymers formed nanoparticles while cetyl-grafted polymers formed polymeric micelles. The flexibility of cetyl chains possibly resulted in the formation of multicore polymeric micelles.
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页码:1511 / 1526
页数:15
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