Combined chelation of lead (II) by deferasirox and deferiprone in rats as biological model

被引：0
|
作者：
F. Dahooee Balooch
S. J. Fatemi
M. Iranmanesh
机构：
[1] Shahid Bahonar University of Kerman,Department of Chemistry, Faculty of Sciences
[2] Islamic Azad University,Department of Chemistry, Faculty of Sciences
来源：
BioMetals | 2014年 / 27卷
关键词：
Lead toxicity; Chelation therapy; Deferasirox; Deferiprone; Rats;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In order to investigate the capability of two chelators deferasirox (DFX or ICL670) and deferiprone (L1) in removing lead from the body, the present research was performed. Two does levels of 40 and 80 mg/kg body weight of lead (II) chloride was given to rats as biological model for 45 days. After 45 days, some toxicity symptoms were observed in rats such as loss of hair and weight, appearance of red dots around eyes, weakness and irritability. After lead application, chelation therapy with DFX and L1 as mono and combined (DFX, L1 and DFX + L1) was done for 10 days. After chelation therapy, lead level in different tissues reduced. The combined chelation therapy results showed that these chelators are able to remove lead from the body and toxicity symptoms decreased. The combined therapy results (DFX + L1) show higher efficacy and lower toxicity compared to single therapies.
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页码：89 / 95
页数：6
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