One-pot non-cyanide synthesis of 1-(pyridin-2-yl)isoquinoline-3-carbonitrile by reaction of 1-phenyl-2-[6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-yl]ethanone with 1,2-dehydrobenzene in the presence of isoamyl nitrite

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作者：
D. S. Kopchuk
I. L. Nikonov
A. P. Krinochkin
I. S. Kovalev
G. V. Zyryanov
V. L. Rusinov
O. N. Chupakhin
机构：
[1] Ural Federal University,Postovskii Institute of Organic Synthesis, Ural Branch
[2] Russian Academy of Sciences,undefined
来源：
Russian Journal of Organic Chemistry | 2017年 / 53卷
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摘要：
The reaction of 1-phenyl-2-[6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-yl]ethanone with 1,2-dehydrobenzene generated in situ from anthranilic acid and excess isoamyl nitrite afforded in one step 1-(pyridin-2-yl)-4-phenylisoquinoline-3-carbonitrile. This reaction may be regarded as a non-cyanide method for the synthesis of 3-cyanoisoquinolines.
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页码：959 / 961
页数：2
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