Dynamic DNA methylation programs persistent adverse effects of early-life stress

被引：0
|
作者：
Chris Murgatroyd
Alexandre V Patchev
Yonghe Wu
Vincenzo Micale
Yvonne Bockmühl
Dieter Fischer
Florian Holsboer
Carsten T Wotjak
Osborne F X Almeida
Dietmar Spengler
机构：
[1] Max Planck Institute of Psychiatry,
来源：
Nature Neuroscience | 2009年 / 12卷
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摘要：
Severe stress in early childhood can increase an individual's vulnerability to depression later in life. This study found that early-life stress in mice resulted in persistent elevation of the stress hormone arginine vasopressin (AVP), which was caused by persistent hypomethylation of CpG islands in the Avp promoter in the hypothalamus.
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页码：1559 / 1566
页数：7
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