Paediatric thrombo-embolism: the influence of non-genetic factors and the role of activated protein C resistance and protein C deficiency

被引：0

作者：

M. M. Uttenreuther-Fischer

B. Vetter

C. Hellmann

U. Otting

S. Ziemer

G. Hausdorf

G. Gaedicke

A. E. Kulozik

机构：

[1] Charité-Virchow Medical Center,

[2] Department of General Paediatrics,undefined

[3] Augustenburger Platz 1,undefined

[4] D-13353 Berlin,undefined

[5] Germany Tel.: +49 30 45066351/2 Fax: +49 30 45066919,undefined

[6] Charité-Virchow Medical Center,undefined

[7] Institute for Pathological and Clinical Biochemistry,undefined

[8] Schumannstrasse 20–21,undefined

[9] D-10098 Berlin,undefined

[10] Germany,undefined

[11] Charité-Virchow Medical Center,undefined

[12] Department of Paediatric Cardiology,undefined

[13] Schumannstrasse 20–21,undefined

[14] D-10098 Berlin,undefined

[15] Germany,undefined

来源：

European Journal of Pediatrics | 1997年 / 156卷

关键词：

Keywords Thrombosis ; Activated protein C resistance ; Protein C deficiency;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In many children, the pathogenesis of thrombo-embolism remains unexplained. This study examines the role of non-genetic risk factors in 37 children with venous or arterial thrombosis. Included were 17 patients with portal vein thrombosis following umbilical vein catheterisation, 6 with portal vein thrombosis and an uneventful neonatal period, 4 with deep vein␣thrombosis, 4 with renal vein thrombosis after kidney transplantation, 1 haemodialysis patient with thromboses of arteriovenous shunts, and 5 with arterial thromboses at various sites. In 25 of these 37 patients (68%) exogenic risk factors and particularly vascular manipulations (24/37) were related to the thrombotic event. Resistance to activated protein C was identified in 5 patients and protein C deficiency in 2 (7/37; 19%). This prevalence was significantly higher than that of the control group (14/243; 5.8%; χ2, P < 0.008).

引用

页码：277 / 281

页数：4