Enzymic synthesis, physicochemical, and cell activity of glucosyl ester derivatives based on N-fatty acyl amino acid

被引：0
|
作者：
Dong An
Dexin Feng
机构：
[1] Qingdao Institute of Bioenergy and Bioprocess Technology,CAS Key Laboratory of Biobased Materials
[2] Chinese Academy of Sciences,undefined
来源：
Chemical Papers | 2019年 / 73卷
关键词：
Amino acid; Antitumor cell lines; Glucosyl ester;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Series of glucosyl esters derivatives were synthesized by enzymatic acylation and some surface properties, and cell activity were calculated and tested. The antitumor activity in vitro against three cancer cells, human colon carcinoma (K562), human hepatoma (HepG2), and human breast adenocarcinoma (MCF-7) of compounds, were evaluated using MTT methods. The glucosyl esters could significantly displayed high anticancer activity. Thereinto, compounds 12 and 12′ showed higher inhibition effect to cancer cells than others. Several compounds were more active than control drug 5-FU. The structure–activity relationship analysis revealed that lipophilic properties might be essential parameter for their activity.
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页码：653 / 662
页数：9
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