Alterations in VHL as potential biomarkers in renal-cell carcinoma

被引：0
|
作者：
Lucy Gossage
Tim Eisen
机构：
[1] Cancer Research UK Cambridge Research Institute,Department of Oncology
[2] Li Ka Shing Centre,undefined
[3] University of Cambridge,undefined
[4] Box 193,undefined
[5] Addenbrookes Hospital,undefined
来源：
Nature Reviews Clinical Oncology | 2010年 / 7卷
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摘要：
Mutations inVHL cause von Hippel–Lindau (VHL) disease, and are common in sporadic clear-cell renal-cell carcinoma (ccRCC). Drugs that modulate the downstream targets of the pVHL/HIF pathway have proven benefit in treating ccRCC. This Review, therefore, discusses the potential role of VHLalterations as prognostic and predictive markers in ccRCC.
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页码：277 / 288
页数：11
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