Primary central nervous system lymphoma

被引：0

作者：

de Koning, Myrthe E. ^{[1
]}

Hof, Jurrit J. ^{[2
]}

Jansen, Casper ^{[3
]}

Doorduijn, Jeanette K. ^{[4
]}

Bromberg, Jacoline E. C. ^{[5
]}

van der Meulen, Matthijs ^{[1
]}

机构：

[1] Med Spectrum Twente, Dept Neurol, Enschede, Netherlands

[2] Med Spectrum Twente, Dept Radiol, Enschede, Netherlands

[3] Lab Pathol Eastern Netherlands, Hengelo, Netherlands

[4] Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Dept Hematol, Rotterdam, Netherlands

[5] Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Dept Neurol, Rotterdam, Netherlands

来源：

JOURNAL OF NEUROLOGY | 2024年 / 271卷 / 05期

关键词：

CNS lymphoma; Neuro-oncology; High-dose methotrexate; Whole brain radiotherapy; INTERNATIONAL EXTRANODAL LYMPHOMA; CNS LYMPHOMA; INTRAOCULAR LYMPHOMA; DIAGNOSIS; SURVIVAL; FEATURES; UTILITY; TRENDS; MRI; PET;

D O I：

10.1007/s00415-023-12143-w

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin lymphoma (NHL) manifesting in the brain, spinal cord, cerebrospinal fluid and/or eyes, in the absence of systemic manifestations. With an increasing incidence and a 30% 5-year overall survival if promptly treated, timely diagnosis and subsequent treatment is paramount. The typical MRI appearance for PCNSL is a solitary or multiple T2-hypointense, homogeneous gadolinium-enhancing lesion with restricted diffusion. Dexamethasone treatment might compromise and delay the diagnosis. Hallmark of treatment is induction with intravenous high-dose methotrexate consisting polychemotherapy followed by consolidation treatment. Consolidation treatment consists of either whole brain radiotherapy (WBRT) or autologous stem cell transplantation (ASCT). Given the (cognitive) side effects of WBRT, ASCT is increasingly being used as the first choice of treatment.

引用

页码：2906 / 2913

页数：8

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