Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population

被引：0
|
作者：
Bo Xiang
Zhenxing Yang
Yin Lin
Lijie Guan
Xuan Li
Wei Deng
Zeyu Jiang
Guohui Lao
Qiang Wang
Xiaoyu Hao
Xiang Liu
Yingcheng Wang
Liansheng Zhao
Xiaohong Ma
Tao Li
Liping Cao
Xun Hu
机构：
[1] Sichuan University,State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital
[2] Sichuan University,Mental Health Center, West China Hospital
[3] Guangzhou Brain Hospital,Biobank, West China Hospital
[4] Sichuan University,undefined
来源：
Neuroscience Bulletin | 2014年 / 30卷
关键词：
bipolar affective disorder; serotonin pathway;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 singlenucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gene and 1/23 SNPs (rs17110566) in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I.
引用
收藏
页码：33 / 42
页数：9
相关论文
共 50 条
  • [1] Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population
    Xiang, Bo
    Yang, Zhenxing
    Lin, Yin
    Guan, Lijie
    Li, Xuan
    Deng, Wei
    Jiang, Zeyu
    Lao, Guohui
    Wang, Qiang
    Hao, Xiaoyu
    Liu, Xiang
    Wang, Yingcheng
    Zhao, Liansheng
    Ma, Xiaohong
    Li, Tao
    Cao, Liping
    Hu, Xun
    [J]. NEUROSCIENCE BULLETIN, 2014, 30 (01) : 33 - 42
  • [2] Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population
    Bo Xiang
    Zhenxing Yang
    Yin Lin
    Lijie Guan
    Xuan Li
    Wei Deng
    Zeyu Jiang
    Guohui Lao
    Qiang Wang
    Xiaoyu Hao
    Xiang Liu
    Yingcheng Wang
    Liansheng Zhao
    Xiaohong Ma
    Tao Li
    Liping Cao
    Xun Hu
    [J]. Neuroscience Bulletin, 2014, 30 (01) : 33 - 42
  • [3] Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population
    Ren, Hongyan
    Guan, Lijie
    Zhao, Liansheng
    Lin, Yin
    Wang, Yincheng
    Yang, Zhenxing
    Li, Xuan
    Ma, Xiaohong
    Cheng, Xiongchao
    Deng, Wenhao
    Aitchison, Katherine J.
    Cao, Liping
    Li, Tao
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2018, 177 (01) : 50 - 67
  • [4] Association analysis of genes in serotonin pathway with attention and executive function in patients with bipolar affective disorder
    Yang, Zhenxing
    Lin, Yin
    Guan, Lijie
    Li, Xuan
    Deng, Wei
    Jiang, Zeyu
    Lao, Guohui
    Wang, Qiang
    Hao, Xiaoyu
    Liu, Xiang
    Wang, Yingcheng
    Zhao, Lianshen
    Ma, Xiaohong
    Cao, Liping
    Li, Tao
    [J]. COMPREHENSIVE PSYCHIATRY, 2014, 55 (08) : 1785 - 1790
  • [5] Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population
    Wen, Zujia
    Chen, Jianhua
    Khan, Raja Amjad Waheed
    Wang, Meng
    Song, Zhijian
    Li, Zhiqiang
    Shen, Jiawei
    Li, Wenjin
    Shi, Yongyong
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 2016, 194 : 180 - 187
  • [6] Exclude association of the serotonin transporter with bipolar disorder in Han Chinese.
    Liu, WQ
    Gu, NF
    Feng, GY
    St Clair, D
    He, L
    [J]. MOLECULAR PSYCHIATRY, 1999, 4 : S92 - S92
  • [7] Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population
    Zeng, Z.
    Wang, T.
    Li, T.
    Li, Y.
    Chen, P.
    Zhao, Q.
    Liu, J.
    Li, J.
    Feng, G.
    He, L.
    Shi, Y.
    [J]. MOLECULAR PSYCHIATRY, 2011, 16 (05) : 473 - 475
  • [8] Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population
    Z Zeng
    T Wang
    T Li
    Y Li
    P Chen
    Q Zhao
    J Liu
    J Li
    G Feng
    L He
    Y Shi
    [J]. Molecular Psychiatry, 2011, 16 : 473 - 475
  • [9] Genetic association analysis of serotonin system genes in bipolar affective disorder
    Vincent, JB
    Masellis, M
    Lawrence, J
    Choi, V
    Gurling, HMD
    Parikh, SV
    Kennedy, JL
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1999, 156 (01): : 136 - 138
  • [10] Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese
    Lin, Yi-Mei J.
    Davamani, Fabian
    Yang, Wei-Chih
    Lai, Te-Jen
    Sun, H. Sunny
    [J]. BEHAVIORAL AND BRAIN FUNCTIONS, 2008, 4 (1)
12345