Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

被引：0

作者：

Maoyi Lai

Alicia Gonzalez-Martin

Anthony B. Cooper

Hiroyo Oda

Hyun Yong Jin

Jovan Shepherd

Linling He

Jiang Zhu

David Nemazee

Changchun Xiao

机构：

[1] The Scripps Research Institute,Department of Immunology and Microbial Science

[2] Kellogg School of Science and Technology,undefined

[3] The Scripps Research Institute,undefined

[4] Present address: Adimab,undefined

[5] 7 Lucent Drive,undefined

[6] Lebanon,undefined

[7] New Hampshire 03766,undefined

[8] USA,undefined

[9] Present address: Department of Immunology and Pathology,undefined

[10] Research Institute,undefined

[11] National Center for Global Health and Medicine,undefined

[12] 1-7-1,undefined

[13] Konodai,undefined

[14] Ichikawa-shi,undefined

[15] Chiba 272-8516,undefined

[16] Japan,undefined

来源：

Nature Communications | / 7卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways.

引用

共 50 条

[1] Regulation of B-cell development and tolerance by different members of the miR-17 ∼ 92 family microRNAs
Lai, Maoyi
Gonzalez-Martin, Alicia
Cooper, Anthony B.
Oda, Hiroyo
Jin, Hyun Yong
Shepherd, Jovan
He, Linling
Zhu, Jiang
Nemazee, David
Xiao, Changchun
NATURE COMMUNICATIONS, 2016, 7
[2] Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas
Mu, Ping
Han, Yoon-Chi
Betel, Doron
Yao, Evelyn
Squatrito, Massimo
Ogrodowski, Paul
de Stanchina, Elisa
D'Andrea, Aleco
Sander, Chris
Ventura, Andrea
GENES & DEVELOPMENT, 2009, 23 (24) : 2806 - 2811
[3] B-cell lymphoma in eα-miR-17∼92 transgenic mice
Sandhu, Sukhinder K.
Neinast, Reid
Balatti, Veronica
Lovat, Francesca
Volinia, Stefano
Pekarsky, Yuri
Croce, Carlo M.
CANCER RESEARCH, 2012, 72
[4] MicroRNAs of the miR-17∼92 family inhibit macrophage activation and inflammation
Zhang, Xiang
Hu, Xiaoyu
JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
[5] MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation
Seung Goo Kang
Wen-Hsien Liu
Peiwen Lu
Hyun Yong Jin
Hyung W Lim
Jovan Shepherd
Daniel Fremgen
Eric Verdin
Michael B A Oldstone
Hai Qi
John R Teijaro
Changchun Xiao
Nature Immunology, 2013, 14 : 849 - 857
[6] MicroRNAs of the miR-17∼92 family inhibit macrophage activation and inflammation
Zhang, X.
Hu, X.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 240 - 240
[7] MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation
Kang, Seung Goo
Liu, Wen-Hsien
Lu, Peiwen
Jin, Hyun Yong
Lim, Hyung W.
Shepherd, Jovan
Fremgen, Daniel
Verdin, Eric
Oldstone, Michael B. A.
Qi, Hai
Teijaro, John R.
Xiao, Changchun
NATURE IMMUNOLOGY, 2013, 14 (08) : 849 - +
[8] B-cell malignancies in microRNA Eμ-miR-17∼92 transgenic mice
Sandhu, Sukhinder K.
Fassan, Matteo
Volinia, Stefano
Lovat, Francesca
Balatti, Veronica
Pekarsky, Yuri
Croce, Carlo M.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (45) : 18208 - 18213
[9] Role of the miR-17∼92 cluster family in cerebellar and medulloblastoma development
Zindy, Frederique
Kawauchi, Daisuke
Lee, Youngsoo
Ayrault, Olivier
Ben Merzoug, Leila
McKinnon, Peter J.
Ventura, Andrea
Roussel, Martine F.
BIOLOGY OPEN, 2014, 3 (07): : 597 - 605
[10] miR-17 ∼92 in lymphocyte development and lymphomagenesis
Labi, Verena
Schoeler, Katia
Melamed, Doron
CANCER LETTERS, 2019, 446 : 73 - 80

← 1 2 3 4 5 →