Synthesis, characterization and biological activities of N-acyl-3-(3-pyridyl)-5-aryl-pyrazoles

被引：0
|
作者：
Yan-fang Kang
Dun-jia Wang
Ben-po Xu
Xian-hong Wei
Jing Zheng
机构：
[1] Hubei Normal University,Hubei Provincial Key Laboratory of Pollutant Analysis and Reuse Technology, College of Chemistry and Environmental Engineering
来源：
Chemical Research in Chinese Universities | 2013年 / 29卷
关键词：
-Acyl-3-(3-pyridyl)-5-aryl-pyrazole; -Diketone; 1; -Pyrazole; Biological activity;
D O I：
暂无
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学科分类号：
摘要：
Ten novel N-acyl-3-(3-pyridyl)-5-aryl-pyrazoles were synthesized by Claisen condensation of the aryl methyl ketones with ethyl nicotinate, the cyclization with hydrazine hydrate and the N-acylation with acyl chloride in turn. The structures of all the compounds synthesized were confirmed by means of Fourier transform infrared(FTIR), 1H NMR, mass spectroscopy and elemental analysis. The biological activities of the title compounds were examined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. All the N-acyl-3-(3-pyridyl)-5-aryl-pyrazoles exhibited a certain degree of antibacterial and antifungal activities. Comparatively, compounds 3c and 3d exhibited much significant antibacterial and antifungal activities than the other pyrazole derivatives.
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页码：227 / 230
页数：3
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