Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

被引：0
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作者：
Di Gao
Ting Chen
Shuojia Chen
Xuechun Ren
Yulong Han
Yiwei Li
Ying Wang
Xiaoqing Guo
Hao Wang
Xing Chen
Ming Guo
Yu Shrike Zhang
Guosong Hong
Xingcai Zhang
Zhongmin Tian
Zhe Yang
机构：
[1] Xi’an Jiaotong University,The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology
[2] John A,Paulson School of Engineering and Applied Sciences
[3] Harvard University,School of Engineering
[4] Massachusetts Institute of Technology,School of Public Health
[5] Guangxi Medical University,Division of Engineering in Medicine, Department of Medicine, Brigham and Womens Hospital
[6] Harvard Medical School,Department of Materials Science and Engineering
[7] Stanford University,undefined
来源：
Nano-Micro Letters | 2021年 / 13卷
关键词：
Photothermal therapy (PTT); Thermodynamic therapy (TDT); Targeting hybrid nanobullet; Hypoxia tumor; Zinc phthalocyanine aggregate (ZPA);
D O I：
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学科分类号：
摘要：
An all-organic hybrid nanobullets labeled as ZPA@HA-ACVA-AZ NBs was developed for the “precise strike”of hypoxic tumors through an oxygen-independently synergistic PTT/TDT, possessing therapeutic advantages over traditional ROS-mediated cancer treatment.By feat of dual-targeting effect from surface-modified HA (targeting CD44 receptors) and AZ (targeting CA IX), the nanobullets accumulated at hypoxic tumors efficiently.The synergism of intelligent nanobullets could suppress the primary breast tumor growth and lung metastasis via CA IX inhibition by AZ and synergistic PTT/TDT.
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