Neurocognitive impairment with hepatitis C and HIV co-infection in Southern Brazil

被引:0
|
作者
Sérgio Monteiro de Almeida
Ana Paula de Pereira
Maria Lucia Alves Pedroso
Clea E. Ribeiro
Indianara Rotta
Bin Tang
Anya Umlauf
Donald Franklin
Rowan G. Saloner
Maria Geny Ribas Batista
Scott Letendre
Robert K. Heaton
Ronald J. Ellis
Mariana Cherner
机构
[1] Universidade Federal do Paraná,Hospital de Clínicas
[2] Faculdades Pequeno Príncipe,UFPR
[3] Instituto de Pesquisa Pelé Pequeno Príncipe,undefined
[4] University of California San Diego,undefined
来源
Journal of NeuroVirology | 2018年 / 24卷
关键词
HCV; HIV-associated neurocognitive disorders (HAND); HIV-1;
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学科分类号
摘要
Although cognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections, research on neurocognitive effects is limited in the context of HIV/HCV co-infection. The aims of this study were to explore the interplay between HIV and HCV infections in the expression of neurocognitive impairment (NCI), and to examine the differences in test performance between HIV/HCV co-infected and HIV or HCV mono-infected patients. A total of 128 participants from Southern Brazil underwent a comprehensive neuropsychological (NP) battery comprising 18 tests. Participants were grouped according to their serological status: HCV mono-infected (n = 20), HIV mono-infected (n = 48), HIV/HCV co-infected (n = 12), and HIV−/HCV-uninfected controls (n = 48). The frequencies of HIV subtypes B and C between the HIV mono-infected and HIV/HCV co-infected groups were comparable. There was greater prevalence of neuropsychological impairment among all three infection groups compared with the uninfected control group, but no statistically significant differences among mono- and co-infected groups were found. HCV infection was associated with cognitive deficits, independently of liver dysfunction. HCV infection did not show an additive effect on neurocognitive function among HIV+. NCI was independent of HCV RNA on peripheral blood, CSF, and hepatic injury. While we did not find additive global effect, in the present study, there was some evidence of additive HIV/HCV co-infection effects in speed of information processing, executive function, and verbal fluency domains when comparing the co-infected group with the other three groups. NP impairment was not dependent on HCV subtypes.
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页码:339 / 349
页数:10
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