NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice

被引：0
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作者：
Lucyna Pomierny-Chamioło
Ewa Poleszak
Andrzej Pilc
Gabriel Nowak
机构：
[1] Jagiellonian University,Department of Toxicology
[2] Collegium Medicum,Department of Pharmacobiology
[3] Jagiellonian University,Department of Neurobiology, Institute of Pharmacology
[4] Collegium Medicum,Department of Drug Management
[5] Polish Academy of Sciences,Department of Applied Pharmacy
[6] Jagiellonian University,undefined
[7] Collegium Medicum,undefined
[8] Skubiszewski Medical University of Lublin,undefined
来源：
Pharmacological Reports | 2010年 / 62卷
关键词：
mGluR; MTEP; forced swim test; NMDA; AMPA; ligands;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several lines of evidence suggest an antidepressant-like activity for 3-[(methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP), a highly selective, non-competitive antagonist of metabotropic glutamate receptors subtype 5 (mGluR5). This effect has been observed following both acute and chronic MTEP treatments in behavioral tests and experimental models of depression, such as the forced swim test (FST), the tail suspension test, and the olfactory bulbectomy model of depression. However, the mechanism of action for mGluR5 antagonists remains unclear.
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页码：1186 / 1190
页数：4
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