A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation

被引：0

作者：

Nina Pirher

Karolina Ivičak

Jelka Pohar

Mojca Benčina

Roman Jerala

机构：

[1] National Institute of Chemistry,Department of Biotechnology

[2] Hajdrihova 19,undefined

[3] Faculty of Chemistry and Chemical Technology,undefined

[4] University of Ljubljana,undefined

来源：

Nature Structural & Molecular Biology | 2008年 / 15卷

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学科分类号：

摘要：

Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA) molecules produced by many viruses and activates an inflammatory response. Synthetic dsRNAs such as small interfering RNAs have been shown to activate TLR3. Now the TLR3 ectodomain is found to contain two dsRNA binding sites, and the implications for dsRNA recognition and selectivity and downstream signaling are discussed.

引用

页码：761 / 763

页数：2

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