Compatibility study between chlorpropamide and excipients in their physical mixtures

被引：0

作者：

Fátima Duarte Freire

C. Flávio Soares Aragão

T. Flávio Accioly de Lima e Moura

Fernanda Nervo Raffin

机构：

[1] Universidade Federal do Rio Grande do Norte–UFRN,Laboratório de Desenvolvimento de Medicamentos–Programa de Pós

[2] NUPLAM–Núcleo de Pesquisa em Alimentos e Medicamentos–Campus Universitário,Graduação em Ciências Farmacêuticas–Departamento de Farmácia

[3] Universidade Federal do Rio Grande do Norte–UFRN,Laboratório de Controle de Qualidade de Medicamentos–Programa de Pós

来源：

Journal of Thermal Analysis and Calorimetry | 2009年 / 97卷

关键词：

Chlorpropamide; Pharmaceutical technology; Thermal analysis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Chlorpropamide ((4-chloro-N-(propylamino)-carbonyl)-benzenesulfonamide) belongs to compounds having sulfonylurea group and is widely used as an oral antidiabetic agent. In this work differential scanning calorimetry (DSC) was used during pre-formulation of chlorpropamide tablets to determine the drug-excipients compatibility. The DSC curves of chlorpropamide and binary mixtures with excipients (sodium croscarmellose, sodium lauryl sulfate, microcrystalline cellulose, magnesium stearate and calcium carbonate) showed that chlorpropamide exhibited interaction with magnesium stearate and sodium lauryl sulfate. The binary mixtures of chlorpropamide–magnesium stearate presented a single endothermic process at 96–108 °C and chlorpropamide–sodium lauryl sulfate showed a wide endotherm at 99–120 °C.

引用

页码：355 / 357

页数：2

共 50 条

[1] Compatibility study between chlorpropamide and excipients in their physical mixtures
Freire, Fatima Duarte
Soares Aragao, C. Flavio
Accioly de Lima e Moura, T. Flavio
Raffin, Fernanda Nervo
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2009, 97 (01) : 355 - 357
[2] Compatibility study between ibuprofen and excipients in their physical mixtures
Tita, Bogdan
Fulias, Adriana
Szabadai, Zoltan
Rusu, Gerlinde
Bandur, Geza
Tita, Dumitru
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2011, 105 (02) : 517 - 527
[3] Compatibility study between indomethacin and excipients in their physical mixtures
Bogdan Tita
Ionut Ledeti
Geza Bandur
Dumitru Tita
Journal of Thermal Analysis and Calorimetry, 2014, 118 : 1293 - 1304
[4] Compatibility Study Between Simvastatin and Excipients in Their Physical Mixtures
Marian, Eleonora
Jurca, Tunde
Kacso, Irina
Borodi, Gheorghe
Rus, Lucia Maria
Bratu, Ioan
REVISTA DE CHIMIE, 2015, 66 (06): : 803 - 807
[5] Compatibility study between indomethacin and excipients in their physical mixtures
Tita, Bogdan
Ledeti, Ionut
Bandur, Geza
Tita, Dumitru
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2014, 118 (02) : 1293 - 1304
[6] Compatibility study between ibuprofen and excipients in their physical mixtures
Bogdan Tiţa
Adriana Fuliaş
Zoltan Szabadai
Gerlinde Rusu
Geza Bandur
Dumitru Tiţa
Journal of Thermal Analysis and Calorimetry, 2011, 105 : 517 - 527
[7] COMPATIBILITY STUDY BETWEEN MAGNESIUM OROTATE AND VARIOUS EXCIPIENTS IN THEIR PHYSICAL MIXTURES
Moisa, Corina
Cadar, Oana
Levei, Erika Andrea
Muresan, Laura
Ganea, Mariana
Nemeth, Sebastian
Cavalu, Simona
Dobjanschi, Luciana
Zdrinca, Mihaela
Barabas, Reka
Banica, Florin
FARMACIA, 2022, 70 (03) : 465 - 476
[8] Compatibility studies of nevirapine in physical mixtures with excipients for oral HAART
de Oliveira, G. G. G.
Ferraz, H. G.
Severino, P.
Souto, E. B.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (02): : 596 - 602
[9] Compatibility study between diazepam and tablet excipients
Matos, A. P. S.
Costa, J. S.
Boniatti, J.
Seiceira, R. C.
Pitaluga, A., Jr.
Oliveira, D. L.
Vicosa, A. L.
Holandino, C.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2017, 127 (02) : 1675 - 1682
[10] Compatibility study between cephalexin monohydrate and some excipients
Hassan, MA
Kaloustian, J
Ramsis, H
Khaled, KA
ElFaham, TH
Tous, SS
Maury, L
Joachim, J
STP PHARMA SCIENCES, 1995, 5 (06): : 435 - 441

← 1 2 3 4 5 →