Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?

被引:0
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作者
Joana Costa
Simona Lucia Bavaro
Sara Benedé
Araceli Diaz-Perales
Cristina Bueno-Diaz
Eva Gelencser
Julia Klueber
Colette Larré
Daniel Lozano-Ojalvo
Roberta Lupi
Isabel Mafra
Gabriel Mazzucchelli
Elena Molina
Linda Monaci
Laura Martín-Pedraza
Cristian Piras
Pedro M. Rodrigues
Paola Roncada
Denise Schrama
Tanja Cirkovic-Velickovic
Kitty Verhoeckx
Caterina Villa
Annette Kuehn
Karin Hoffmann-Sommergruber
Thomas Holzhauser
机构
[1] REQUIMTE-LAQV/Faculdade de Farmácia Universidade do Porto,Instituto de Investigación en Ciencias de la Alimentación (CIAL)
[2] Institute of Sciences of Food Production (ISPA) - National Research Council (CNR),Centro de Biotecnologia y Genomica de Plantas (UPM
[3] Moorepark Food Research Centre,INIA)
[4] CSIC-UAM,Departmento de Bioquímica y Biología Molecular
[5] Universidad Politecnica de Madrid,Department of Biology, Food Science Research Institute
[6] Facultad de Ciencias Químicas de la Universidad Complutense de Madrid,Department of Infection and Immunity
[7] National Agricultural Research and Innovation Centre,Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis
[8] Luxembourg Institute of Health,INRAE
[9] University of Southern Denmark,Precision Immunology Institute, Jaffe Food Allergy Institute
[10] UR 1268,Mass Spectrometry Laboratory, MolSys Research Unit
[11] Biopolymers Interactions Assemblies,Biochemistry and Molecular Biology department, Chemistry Faculty
[12] Icahn School of Medicine at Mount Sinai,Department of Veterinary Medicine
[13] University of Liege,Department of Chemistry
[14] Complutense University of Madrid,CCMAR
[15] University of Milan,Department of Health Sciences
[16] University of Reading,Faculty of Bioscience Engineering
[17] Universidade do Algarve,Department of Dermatology/Allergology
[18] University ‘Magna Græcia’,Department of Pathophysiology and Allergy Research
[19] University of Belgrade - Faculty of Chemistry,undefined
[20] Ghent University Global Campus,undefined
[21] Ghent University,undefined
[22] University Medical Center Utrecht,undefined
[23] Medical University of Vienna,undefined
[24] Division of Allergology Paul-Ehrlich-Institut,undefined
关键词
Plant allergens; Protein families; Allergenicity; Food processing; Matrix effect;
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摘要
This review searched for published evidence that could explain how different physicochemical properties impact on the allergenicity of food proteins and if their effects would follow specific patterns among distinct protein families. Owing to the amount and complexity of the collected information, this literature overview was divided in two articles, the current one dedicated to protein families of plant allergens and a second one focused on animal allergens. Our extensive analysis of the available literature revealed that physicochemical characteristics had consistent effects on protein allergenicity for allergens belonging to the same protein family. For example, protein aggregation contributes to increased allergenicity of 2S albumins, while for legumins and cereal prolamins, the same phenomenon leads to a reduction. Molecular stability, related to structural resistance to heat and proteolysis, was identified as the most common feature promoting plant protein allergenicity, although it fails to explain the potency of some unstable allergens (e.g. pollen-related food allergens). Furthermore, data on physicochemical characteristics translating into clinical effects are limited, mainly because most studies are focused on in vitro IgE binding. Clinical data assessing how these parameters affect the development and clinical manifestation of allergies is minimal, with only few reports evaluating the sensitising capacity of modified proteins (addressing different physicochemical properties) in murine allergy models. In vivo testing of modified pure proteins by SPT or DBPCFC is scarce. At this stage, a systematic approach to link the physicochemical properties with clinical plant allergenicity in real-life scenarios is still missing.
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页码:37 / 63
页数:26
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