FTD and ALS—translating mouse studies into clinical trials

被引：0
|
作者：
Lars M. Ittner
Glenda M. Halliday
Jillian J. Kril
Jürgen Götz
John R. Hodges
Matthew C. Kiernan
机构：
[1] Dementia Research Unit,
[2] School of Medical Sciences,undefined
[3] Wallace Wurth Building East,undefined
[4] The University of New South Wales,undefined
[5] The University of New South Wales and Neuroscience Research Australia,undefined
[6] Disciplines of Medicine and Pathology,undefined
[7] Sydney Medical School,undefined
[8] Edward Ford Building A27,undefined
[9] The University of Sydney,undefined
[10] Clem Jones Centre for Ageing Dementia Research,undefined
[11] Queensland Brain Institute,undefined
[12] The University of Queensland,undefined
[13] Brain and Mind Research Institute,undefined
[14] The University of Sydney,undefined
来源：
Nature Reviews Neurology | 2015年 / 11卷
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摘要：
The symptoms and neuropathology of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) can show a high degree of overlap, and few effective treatments exist for these conditions. In this Perspectives article, Ittner and colleagues describe recent failures in the translation of data from mouse models into clinical trials for patients with FTD and/or ALS. The authors summarize the strengths and weaknesses of several available mouse models, and make recommendations for improving future research practice.
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页码：360 / 366
页数：6
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