Nuclear survivin as a biomarker for non-small-cell lung cancer

被引：0
|
作者：
B Lu
A Gonzalez
P P Massion
Y Shyr
B Shaktour
D P Carbone
D E Hallahan
机构：
[1] Vanderbilt Ingram,Department of Radiation Oncology
[2] Cancer Center,Department of Pathology
[3] Vanderbilt University School of Medicine,Department of Medicine
[4] Vanderbilt Ingram,Department of Preventive Medicine
[5] Cancer Center,undefined
[6] Vanderbilt University School of Medicine,undefined
[7] Vanderbilt Ingram,undefined
[8] Cancer Center,undefined
[9] Vanderbilt University School of Medicine,undefined
[10] Vanderbilt Ingram,undefined
[11] Cancer Center,undefined
[12] Vanderbilt University School of Medicine,undefined
来源：
British Journal of Cancer | 2004年 / 91卷
关键词：
survivin; lung cancer; nucleus; tissue array; mitosis; apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.
引用
收藏
页码：537 / 540
页数：3
相关论文
共 50 条
  • [1] Nuclear survivin as a biomarker for non-small-cell lung cancer
    Lu, B
    Gonzalez, A
    Massion, PP
    Shyr, Y
    Shaktour, B
    Carbone, DP
    Hallahan, DE
    BRITISH JOURNAL OF CANCER, 2004, 91 (03) : 537 - 540
  • [2] Nuclear staining of survivin as a biomarker for non-small-cell lung cancer
    Lu, B
    Gonzalez, A
    Massion, P
    Shyr, Y
    Chen, C
    Li, M
    Freyer, A
    Olson, S
    Hallahan, D
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 60 (01): : S528 - S528
  • [3] Nuclear survivin predicts relapse and poor survival of resected non-small-cell lung cancer
    Lu, B
    Gonzalez, A
    Massion, P
    Shinohara, E
    Carbone, D
    Johnson, D
    Shyr, Y
    Hallahan, D
    LUNG CANCER, 2005, 49 : S292 - S292
  • [4] Effect and biomarker of Nivolumab for non-small-cell lung cancer
    Wang, Li
    Zhao, Deze
    Qin, Kang
    Ul Rehman, Faisal
    Zhang, Xiaochun
    BIOMEDICINE & PHARMACOTHERAPY, 2019, 117
  • [5] Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancer
    Vischioni, B
    van der Valk, P
    Span, SW
    Kruyt, FAE
    Rodriguez, JA
    Giaccone, G
    ANNALS OF ONCOLOGY, 2004, 15 (11) : 1654 - 1660
  • [6] Nuclear and, cytoplasmic cellular distribution of survivin as survival predictor in resected non-small-cell lung cancer
    Bria, E.
    Visca, P.
    Novelli, F.
    Casini, B.
    Diodoro, M. G.
    Perrone-Donnorso, R.
    Botti, C.
    Sperduti, I.
    Facciolo, F.
    Milella, M.
    Cecere, F. L.
    Cognetti, F.
    Mottolese, M.
    EJSO, 2008, 34 (05): : 593 - 598
  • [7] Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer
    Tanabe, H
    Yagihashi, A
    Tsuji, N
    Shijubo, Y
    Abe, S
    Watanabe, N
    LUNG CANCER, 2004, 46 (03) : 299 - 304
  • [8] New method to identify non-small-cell lung cancer biomarker
    Hill, Rosanna
    BIOANALYSIS, 2013, 5 (19) : 2337 - 2337
  • [9] Nuclear Survivin Expression in Small Cell Lung Cancer
    Yano, Yukihiro
    Otsuka, Tomoyuki
    Hirano, Hiroshi
    Uenami, Takeshi
    Satomi, Akitoshi
    Kuroyama, Muneyoshi
    Niinaka, Manabu
    Yoneda, Tsutomu
    Kimura, Hiromi
    Mori, Masahide
    Yamaguchi, Toshihiko
    Yokota, Soichiro
    ANTICANCER RESEARCH, 2015, 35 (05) : 2935 - 2939
  • [10] Non-Small-Cell Lung Cancer
    不详
    GENETIC ENGINEERING & BIOTECHNOLOGY NEWS, 2008, 28 (20): : 61 - 61
12345