Synthesis and biological activity of 9-dialkylaminoethyl-2-oxy(dioxy)- phenylimidazo[1,2-a]benzimidazoles

被引：0
|
作者：
Anisimova V.A. [1 ]
Spasov A.A. [2 ]
Kosolapov V.A. [2 ]
Chernikov M.V. [2 ]
Stukovina A.Yu. [2 ]
El'tsova L.V. [2 ]
Larionov N.P. [2 ]
Libinzon R.E. [3 ]
Vatolkina O.E. [3 ]
机构：
[1] Research Institute of Physical and Organic Chemistry, Rostov State University, Rostov-on-Don
[2] Volgograd State Medical Academy, Volgograd
[3] All-Russia Scientific Center for Safety Testing of Biologically Active Substances, Ministry of Public Health of the Russian Federation, Staraya Kupavna, Moscow Oblast
来源：
Pharmaceutical Chemistry Journal | 2006年 / 40卷 / 10期
关键词：
EtOH; Reference Drug; Cinnarizine; cAMP Phosphodiesterase; Dioxy;
D O I：
10.1007/s11094-006-0185-5
中图分类号：
学科分类号：
摘要：
A series of 9-dialkylaminoethyl-2-oxy(dioxy)phenylimidazo[1,2-a] benzimidazoles have been synthesized and their pharmacological properties have been studied. Some compounds exhibit pronounced antioxidant activity, as confirmed on experimental pathological models in animals. The tests also revealed membranotropic, spasmolytic, antiaggregant, hemorheological, anticalmodulin, antiulcer, and hypotensive activity, and the properties of serotonin 5-HT2 and 5-HT3 receptor antagonists. The results confirm good prospects for the synthesis and screening of biologically active substances among benzimidazoles of this series. © 2006 Springer Science+Business Media, Inc.
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页码：521 / 529
页数：8
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