Association of genetic variations in RTN4 3′-UTR with risk for clear cell renal cell carcinoma

被引:0
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作者
Yan Pu
Peng Chen
Bin Zhou
Peng Zhang
Yanyun Wang
Yaping Song
Lin Zhang
机构
[1] Sichuan University,Department of Forensic Biology, West China School of Basic Sciences and Forensic Medicine
[2] Nanjing Medical University,Department of Forensic Medicine
[3] Sichuan University,Laboratory of Molecular Translational Medicine, West China Institute of Women and Children’s Health, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Universit
[4] Sichuan University,Department of Urology, West China Hospital
来源
Familial Cancer | 2018年 / 17卷
关键词
Nogo proteins; Clear cell renal cell carcinoma; Polymorphism; Genetic susceptibility;
D O I
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中图分类号
学科分类号
摘要
Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. The present study was conducted to evaluate whether the TATC (rs71682980) and CAA (rs34917480) insertion/deletion polymorphisms of RTN4 3′-UTR are associated with clear cell renal cell carcinoma (ccRCC). These two polymorphisms were genotyped in 308 ccRCC patients and 466 healthy controls by polymerase chain reaction polyacrylamide gel electrophoresis (PCR-PAGE). Significantly reduced ccRCC risk was observed to be associated with the TATCins/ins genotype carriers (Versus TATCdel/del: adjusted OR 0.53, 95% CI 0.32–0.87, P = 0.022; Versus TATCdel/del−del/ins: adjusted OR 0.57, 95% CI 0.36–0.92, P = 0.017). After performing stratification analysis, the frequency of TATCins/ins genotype was observed to be significantly higher in patients with N0 compared the patients with N1 (P = 0.003). The present study provide evidence for the first time that the TATC insertion/deletion polymorphism in RTN4 3′-UTR may contributes to ccRCC risk in Chinese Han population.
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页码:129 / 134
页数:5
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