Prospecting for molecular glues

被引：0
|
作者：
Willem den Besten
J. Russell Lipford
机构：
[1] Amgen Research,Department of Oncology Research
来源：
Nature Chemical Biology | 2020年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two recent studies identified CDK12 inhibitors that bind to CDK12–cyclin K complexes and act as molecular glues to stabilize an interaction with the ubiquitin ligase CUL4–DDB1, leading to cyclin K degradation.
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页码：1157 / 1158
页数：1
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