Cells often migrate in tightly connected groups with coordinated movement and polarity. The collective migration of epithelial cell sheets is now shown to be mediated by a signalling axis that involves the merlin tumour-suppressor protein, the tight-junction-associated angiomotin–Rich1 complex and the Rac1 small GTPase.
机构:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, Cell Biol Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, Cell Biol Program, New York, NY 10021 USA
Okada, Tomoyo
You, Liru
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机构:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, Cell Biol Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, Cell Biol Program, New York, NY 10021 USA
You, Liru
Giancotti, Filippo G.
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Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, Cell Biol Program, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Sloan Kettering Inst Canc Res, Cell Biol Program, New York, NY 10021 USA