In this article, our aim was to share our clinical experience regarding the effectiveness and the side effects of amisulpride treatment in adolescent cases. We reviewed all the cases who had amisulpride treatment during their stay in a newly opened in-patient unit, and three female cases who had undergone amisulpride treatment. We observed that the drug was effective and caused side effects like galactorrhea due to increased prolactin levels, which were not severe enough to terminate the treatment. Our clinical experience provides preliminary evidence that amisulpride might be an effective antipsychotic drug for adolescent cases. However, it caused considerable side effects.