A case of scrapie in a sheep carrying the lysine-171 allele of the prion protein gene

被引：0

作者：

P. L. Acutis

F. Martucci

M. Mazza

S. Peletto

B. Iulini

C. Corona

E. Bozzetta

C. Casalone

M. Caramelli

机构：

[1] CEA – Istituto Zooprofilattico Sperimentale del Piemonte,

[2] Liguria e Valle d’Aosta,undefined

来源：

Archives of Virology | 2006年 / 151卷

关键词：

Prion Protein; Bovine Spongiform Encephalopathy; Scrapie; Prion Protein Gene; Natural Scrapie;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Susceptibility to scrapie in sheep depends on the host PrP genotype. No data about the linkage of the rare ARK allele to differential scrapie susceptibility are currently available. Several tissues isolated from sheep from an Italian scrapie outbreak and carrying the ARK allele were examined for the presence of the pathological prion protein. A weak positivity was detected only by Western blot in the brainstem of one ARK/ARH sheep. This result shows that the ARK allele does not confer full resistance against scrapie and that the allele needs to be studied further before it can be considered for breeding purposes.

引用

页码：1875 / 1880

页数：5

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