Presence of metabolic risk factors in non-obese PCOS sisters: Evidence of heritability of insulin resistance

被引：0
|
作者：
E. Diamanti-Kandarakis
K. Alexandraki
A. Bergiele
H. Kandarakis
G. Mastorakos
A. Aessopos
机构：
[1] Athens University School of Medicine,Endocrine Section, First Department of Internal Medicine
[2] Laiko General Hospital,Endocrine Unit, 2nd Department of Obstetrics and Gynecology, Aretaeion Hospital
[3] Athens University School of Medicine,undefined
来源：
Journal of Endocrinological Investigation | 2004年 / 27卷
关键词：
PCOS; PCOS families; PCOS sisters; insulin resistance; hyperinsulinemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study was performed to determine whether phenotypically healthy sisters of women with polycystic ovary syndrome (PCOS) have evidence of insulin resistance. We studied 54 women: 17 with PCOS, 17 sisters of these probands and 20 control women with similar age, body mass index (BMI) and waist-to-hip ratio (WHR). The PCOS sisters had neither clinical nor laboratory evidence of hyperandrogenism. However, estimated insulin resistance indices indicated decreased insulin sensitivity in PCOS sisters compared with the controls. No difference of insulin resistance indices was detected between the PCOS and their sisters. This finding provides additional evidence that there is a hereditary trait regarding insulin resistance in the PCOS families.
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页码：931 / 936
页数：5
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