Endothelial progenitor cells for postnatal vasculogenesis

被引:87
|
作者
Eguchi M. [1 ]
Masuda H. [1 ]
Asahara T. [1 ,2 ]
机构
[1] Department of Regenerative Medicine Science, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Bohseidai
[2] Stem Cell Translational Research, Institute of Biomedical Research and Innovation, RIKEN Center for Developmental Biology, Kobe
关键词
Angiogenesis; Cardiovascular disease; Cell therapy; Endothelial progenitor cells (EPCs); Renal stem cell; Therapeutic neovascularization; Vasculogenesis;
D O I
10.1007/s10157-006-0448-1
中图分类号
学科分类号
摘要
Bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation, are augmented in response to certain cytokines and/or tissue ischemia, and are home to - as well as incorporate into - sites of neovascularization. On the basis of these aspects, EPCs have attractive potential therapeutic applications for cardiovascular ischemic diseases as a novel cell-based strategy, mainly via a vasculogenesis mechanism. This review provides an update of the biology of EPCs, as well as highlighting the potential use of these cells for therapeutic regeneration. © 2007 Japanese Society of Nephrology.
引用
收藏
页码:18 / 25
页数:7
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