Counselling framework for moderate-penetrance cancer-susceptibility mutations

被引：0

作者：

Nadine Tung

Susan M. Domchek

Zsofia Stadler

Katherine L. Nathanson

Fergus Couch

Judy E. Garber

Kenneth Offit

Mark E. Robson

机构：

[1] Beth Israel Deaconess Medical Center,Nadine Tung is at the Division of Hematology

[2] 330 Brookline Avenue,Oncology

[3] Boston,and the Department of Medicine

[4] Massachusetts 02215,Fergus Couch is at the Department of Laboratory Medicine and Pathology

[5] USA.,undefined

[6] Susan M. Domchek and Katherine L. Nathanson are at the Abramson Cancer Center,undefined

[7] 3400 Spruce Street,undefined

[8] Philadelphia,undefined

[9] Pennsylvania 19104,undefined

[10] USA,undefined

[11] Perelman School of Medicine,undefined

[12] University of Pennsylvania,undefined

[13] 3400 Civic Center Boulevard,undefined

[14] Philadelphia,undefined

[15] Pennsylvania 19104,undefined

[16] USA.,undefined

[17] Zsofia Stadler,undefined

[18] Kenneth Offit,undefined

[19] and Mark E. Robson are at the Clinical Genetics Service,undefined

[20] Memorial Sloan Kettering Cancer Center,undefined

[21] 1275 York Avenue,undefined

[22] the Weill Cornell Medical College,undefined

[23] 1300 York Avenue,undefined

[24] New York,undefined

[25] New York 10065,undefined

[26] USA.,undefined

[27] Mayo Clinic,undefined

[28] 200 First Street South West,undefined

[29] Rochester,undefined

[30] Minnesota 55905,undefined

[31] USA.,undefined

[32] Judy E. Garber is at the Dana–Farber Cancer Institute,undefined

[33] 450 Brookline Avenue,undefined

[34] Boston,undefined

[35] Massachusetts 02215,undefined

[36] USA.,undefined

来源：

Nature Reviews Clinical Oncology | 2016年 / 13卷

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学科分类号：

摘要：

The use of multigene panels for the assessment of cancer susceptibility is expanding rapidly in clinical practice. The appropriate management of individuals harbouring moderate-penetrance genetic variants in individuals referred for clinical testing is unclear. The authors of this Perspectives article provide a framework for clinical decision-making pending the development of a sufficient evidence base to document the clinical utility of the interventions for individuals with inherited moderate-penetrance gene mutations associated with an increased risk of cancer.

引用

页码：581 / 588

页数：7

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