Expression of KIR2DL3 and KIR2DS2 Natural Killer Receptors in Exercise

被引：0

作者：

V. A. Shleptsova

E. S. Grebenyuk

S. A. Khaustova

N. P. Obraztsova

M. Yu. Shkurnikov

D. A. Sakharov

E. A. Tonevitsky

机构：

[1] Institute of Physical Culture and Sports,

来源：

Bulletin of Experimental Biology and Medicine | 2010年 / 149卷

关键词：

immune system; gene expression; natural killers; exercise;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The mechanisms of early activation of natural killers were studied in volunteers of different athletic qualification. The initial levels of expression of KIR2DL2, PRF1, and GZMB genes regulating the functions of natural killer differ in athletes and untrained subjects. Moderate exercise stimulates transcription activities of these genes. In athletes, the expression increases more intensely than in controls. Stimulation of inhibitory (KIR2DL3) and activation (KIR2DS2) receptors was revealed. This indicated nonspecific stimulation of natural killers, probably mediated by an increase in serum concentration of heat shock protein with a molecular weight of 70 kDa.

引用

页码：755 / 758

页数：3

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