Temperature Dependence of Bimolecular Reactions Associated with Molecular Mobility in Lyophilized Formulations

被引：0
|
作者：
Sumie Yoshioka
Yukio Aso
Shigeo Kojima
机构：
[1] National Institute of Health Sciences,
[2] National Institute of Health Sciences,undefined
来源：
Pharmaceutical Research | 2000年 / 17卷
关键词：
acetyl transfer; hydrolysis; lyophilized formulation; temperature dependence; molecular mobility;
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学科分类号：
摘要：
Purpose. We studied the temperature dependence of acetyltransfer between aspirin and sulfadiazine, a bimolecular reaction, inlyophilized formulations at temperatures near the glass transitiontemperature (Tg) and NMR relaxation-based critical mobilitytemperature (Tmc), to further understand the effect of molecularmobility on chemical degradation rates in solid pharmaceutical formulations.The temperature dependence of the hydrolysis rates of aspirin andcephalothin in lyophilized formulations was also studied as a model ofbimolecular reactions in which water is a reactant.
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页码：925 / 929
页数：4
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