Synthesis and Some Transformations of (2,2-Dimethyl-4-propyltetrahydro-2H-pyran-4-yl)acetonitrile

被引：0
|
作者：
N. S. Arutyunyan
L. A. Akopyan
N. Z. Akopyan
G. A. Panosyan
G. A. Gevorgyan
机构：
[1] National Academy of Sciences of the Republic of Armenia,Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
[2] National Academy of Sciences of the Republic of Armenia,Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
来源：
Russian Journal of General Chemistry | 2018年 / 88卷
关键词：
azomethines; amides; amines; azomethines reduction;
D O I：
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中图分类号：
学科分类号：
摘要：
Removal of the ethoxycarbonyl group in ethyl cyano-(2,2-dimethyl-4-propyltetrahydro-2H-pyran-4 -yl)acetate afforded the corresponding (2,2-dimethyl-4-propyltetrahydro-2H-pyran-4-yl)acetonitrile. The reduction of the latter with lithium aluminum hydride furnished 2-(2,2-dimethyl-4-propyltetrahydro-2H-pyran- 4-yl)ethanamine, which reacted with furfural and a heterocyclic ketone followed by reduction to form the secondary amines and some amides. Hydrolysis of the above nitrile resulted in the corresponding acid, which was converted in a series of amides.
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页码：1537 / 1541
页数：4
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