Palladium-catalysed transannular C–H functionalization of alicyclic amines

被引：0
|
作者：
Joseph J. Topczewski
Pablo J. Cabrera
Noam I. Saper
Melanie S. Sanford
机构：
[1] University of Michigan,Department of Chemistry
[2] 930 North University Avenue,undefined
来源：
Nature | 2016年 / 531卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An approach to selectively manipulate the C–H bonds of alicyclic amines at sites remote to nitrogen is demonstrated by the synthesis of new derivatives of several bioactive molecules, including varenicline, a drug used to treat nicotine addiction.
引用
收藏
页码：220 / 224
页数：4
相关论文
共 50 条
  • [1] Palladium-catalysed transannular C-H functionalization of alicyclic amines
    Topczewski, Joseph J.
    Cabrera, Pablo J.
    Saper, Noam I.
    Sanford, Melanie S.
    [J]. NATURE, 2016, 531 (7593) : 220 - 224
  • [2] Model Complexes for the Palladium-Catalyzed Transannular C-H Functionalization of Alicyclic Amines
    Aguilera, Ellen Y.
    Sanford, Melanie S.
    [J]. ORGANOMETALLICS, 2019, 38 (01) : 138 - 142
  • [3] Palladium-Mediated Cγ-H Functionalization of Alicyclic Amines
    Aguilera, Ellen Y.
    Sanford, Melanie S.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (20) : 11227 - 11230
  • [4] Palladium-catalysed norbornene-mediated C–H functionalization of arenes
    Juntao Ye
    Mark Lautens
    [J]. Nature Chemistry, 2015, 7 : 863 - 870
  • [5] Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides
    Pankaj Jain
    Pritha Verma
    Guoqin Xia
    Jin-Quan Yu
    [J]. Nature Chemistry, 2017, 9 (2) : 140 - 144
  • [6] Palladium-catalysed norbornene-mediated C-H functionalization of arenes
    Ye, Juntao
    Lautens, Mark
    [J]. NATURE CHEMISTRY, 2015, 7 (11) : 863 - 870
  • [7] Enantioselective amine α-functionalization via palladium-catalysed C-H arylation of thioamides
    Jain, Pankaj
    Verma, Pritha
    Xia, Guoqin
    Yu, Jin-Quan
    [J]. NATURE CHEMISTRY, 2017, 9 (02) : 140 - 144
  • [8] Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles
    Andrew McNally
    Benjamin Haffemayer
    Beatrice S. L. Collins
    Matthew J. Gaunt
    [J]. Nature, 2014, 510 : 129 - 133
  • [9] Palladium-Catalysed Synthesis of α-(Trifluoromethyl)styrenes by Means of Directed C-H Bond Functionalization
    Zhao, Qun
    Besset, Tatiana
    Poisson, Thomas
    Bouillon, Jean-Philippe
    Pannecoucke, Xavier
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 2016 (01) : 76 - 82
  • [10] Palladium-catalysed C-H activation of aliphatic amines to give strained nitrogen heterocycles
    McNally, Andrew
    Haffemayer, Benjamin
    Collins, Beatrice S. L.
    Gaunt, Matthew J.
    [J]. NATURE, 2014, 510 (7503) : 129 - 133
12345