Biomarkers and diagnostic tools for detection of Helicobacter pylori

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作者
Akbar Khalilpour
Mehdi Kazemzadeh-Narbat
Ali Tamayol
Rahmi Oklu
Ali Khademhosseini
机构
[1] Harvard Medical School,Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital
[2] Massachusetts Institute of Technology,Harvard
[3] Mayo Clinic,Massachusetts Institute of Technology Division of Health Sciences and Technology
[4] Harvard University,Division of Vascular and Interventional Radiology
[5] King Abdulaziz University,Wyss Institute for Biologically Inspired Engineering
[6] Konkuk University,Department of Physics
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关键词
Infection markers; Diagnostic kits; Microfluidic systems;
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摘要
Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world’s population. H. pylori is associated with significant morbidity and mortality including gastric cancer. The infection has both direct and indirect impacts on economic and overall well-being of patients; hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits. Here, we briefly review general aspects of H. pylori infection and the diagnostic biomarkers used in laboratory tests today with a focus on the potential role of microfluidic systems in future immunodiagnosis platforms.
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页码:4723 / 4734
页数:11
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