Gut microbiota composition correlates with diet and health in the elderly

被引：0

作者：

Marcus J. Claesson

Ian B. Jeffery

Susana Conde

Susan E. Power

Eibhlís M. O’Connor

Siobhán Cusack

Hugh M. B. Harris

Mairead Coakley

Bhuvaneswari Lakshminarayanan

Orla O’Sullivan

Gerald F. Fitzgerald

Jennifer Deane

Michael O’Connor

Norma Harnedy

Kieran O’Connor

Denis O’Mahony

Douwe van Sinderen

Martina Wallace

Lorraine Brennan

Catherine Stanton

Julian R. Marchesi

Anthony P. Fitzgerald

Fergus Shanahan

Colin Hill

R. Paul Ross

Paul W. O’Toole

机构：

[1] University College Cork,Department of Microbiology

[2] Alimentary Pharmabiotic Centre,Department of Statistics

[3] University College Cork,Department of Epidemiology and Public Health

[4] University College Cork,Department of Medicine

[5] Teagasc,undefined

[6] Moorepark Food Research Centre,undefined

[7] Moorepark,undefined

[8] Fermoy,undefined

[9] Co,undefined

[10] Cork,undefined

[11] Ireland ,undefined

[12] Cork University Hospital,undefined

[13] Wilton,undefined

[14] Cork,undefined

[15] Ireland ,undefined

[16] St. Finbarr’s Hospital,undefined

[17] Douglas Road,undefined

[18] Cork,undefined

[19] Ireland ,undefined

[20] Mercy University Hospital,undefined

[21] Grenville Place,undefined

[22] Cork,undefined

[23] Ireland ,undefined

[24] South Infirmary,undefined

[25] Victoria University Hospital,undefined

[26] Institute of Food and Health,undefined

[27] University College Dublin,undefined

[28] School of Biosciences,undefined

[29] Cardiff University,undefined

[30] Museum Avenue,undefined

[31] Cardiff CF10 3AT,undefined

[32] UK ,undefined

[33] University College Cork,undefined

[34] University College Cork,undefined

来源：

Nature | 2012年 / 488卷

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摘要：

Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

引用

页码：178 / 184

页数：6

共 50 条

[1] Gut microbiota composition correlates with diet and health in the elderly
Claesson, Marcus J.
Jeffery, Ian B.
Conde, Susana
Power, Susan E.
O'Connor, Eibhlis M.
Cusack, Siobhan
Harris, Hugh M. B.
Coakley, Mairead
Lakshminarayanan, Bhuvaneswari
O'Sullivan, Orla
Fitzgerald, Gerald F.
Deane, Jennifer
O'Connor, Michael
Harnedy, Norma
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O'Mahony, Denis
van Sinderen, Douwe
Wallace, Martina
Brennan, Lorraine
Stanton, Catherine
Marchesi, Julian R.
Fitzgerald, Anthony P.
Shanahan, Fergus
Hill, Colin
Ross, R. Paul
O'Toole, Paul W.
[J]. NATURE, 2012, 488 (7410) : 178 - +
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