In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

被引：0

作者：

Joji Fujisaki

Juwell Wu

Alicia L. Carlson

Lev Silberstein

Prabhakar Putheti

Rafael Larocca

Wenda Gao

Toshiki I. Saito

Cristina Lo Celso

Hitoshi Tsuyuzaki

Tatsuyuki Sato

Daniel Côté

Megan Sykes

Terry B. Strom

David T. Scadden

Charles P. Lin

机构：

[1] Advanced Microscopy Program,Harvard

[2] Center for Systems Biology and Wellman Center for Photomedicine,MIT Division of Health Sciences and Technology

[3] Massachusetts General Hospital,Transplantation Institute and Department of Medicine

[4] Harvard Medical School,Département de Physique

[5] CPZN 8238,undefined

[6] 185 Cambridge Street,undefined

[7] Boston,undefined

[8] Massachusetts 02114,undefined

[9] USA ,undefined

[10] Harvard Stem Cell Institute,undefined

[11] 42 Church Street,undefined

[12] 77 Massachusetts Avenue,undefined

[13] E25-519,undefined

[14] Cambridge,undefined

[15] Massachusetts 02139,undefined

[16] USA,undefined

[17] Center for Regenerative Medicine,undefined

[18] Massachusetts General Hospital,undefined

[19] 185 Cambridge Street,undefined

[20] Boston,undefined

[21] Massachusetts 02114,undefined

[22] USA ,undefined

[23] Beth Israel Deaconess Medical Center,undefined

[24] Bone Marrow Transplantation Section,undefined

[25] Transplantation Biology Research Center,undefined

[26] Massachusetts General Hospital,undefined

[27] MGH-East,undefined

[28] Bldg.149-5102 13th Street,undefined

[29] Boston,undefined

[30] Massachusetts 02129,undefined

[31] USA ,undefined

[32] Faculty of Medicine,undefined

[33] The University of Tokyo,undefined

[34] 7-3-1 Hongo,undefined

[35] Bunkyo-ku,undefined

[36] Tokyo 113-0033,undefined

[37] Japan ,undefined

[38] Génie Physique et Optique & Centre de Recherche Université Laval Robert-Giffard,undefined

[39] Québec City,undefined

[40] Québec G1J 2G3,undefined

[41] Canada,undefined

[42] Present addresses: Department of Regenerative Medicine,undefined

[43] Clinical Research Center,undefined

[44] National Hospital Organization Nagoya Medical Center,undefined

[45] 4-1-1 Sannomaru,undefined

[46] Naka-ku,undefined

[47] Nagoya Aichi 460-0001,undefined

[48] Japan (T.I.S.); Columbia Center for Translational Immunology,undefined

[49] Columbia University Medical Center,undefined

[50] 650 W. 168th Street,undefined

来源：

Nature | 2011年 / 474卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

A new study identifies the bone marrow haematopoietic stem cell (HSC) niche — a specialized microenvironment where stem cells reside — as an immune privileged site. This property is known to exist in the testis, ovary and hair follicle but has not been universally demonstrated in all stem cell niches. High-resolution in vivo imaging shows the accumulation of regulatory T cells in the HSC niche, enabling transplanted allo-HSCs to escape from allogeneic rejection. As well as supporting stem-cell function, the niche may provide a relative sanctuary from immune attack that could extend to malignant cells in some instances.

引用

页码：216 / 219

页数：3

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