Mutagenesis in rodents using the L1 retrotransposon

被引：0
|
作者：
Ostertag E.M. [1 ,2 ]
Madison B.B. [1 ]
Kano H. [1 ]
机构：
[1] University of Pennsylvania School of Medicine, Department of Genetics, Philadelphia, PA 19104, Curie Blvd
[2] University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104, Curie Blvd
来源：
Genome Biology | / 8卷 / Suppl 1期
关键词：
Enhanced Green Fluorescent Protein; Long Terminal Repeat; Gene Trap; Long Terminal Repeat Retrotransposons; Heterologous Promoter;
D O I：
10.1186/gb-2007-8-s1-s16
中图分类号：
学科分类号：
摘要：
LINE1 (L1) retrotransposons are genetic elements that are present in all mammalian genomes. L1s are active in both humans and mice, and are capable of copying themselves and inserting the copy into a new genomic location. These de novo insertions occasionally result in disease. Endogenous L1 retrotransposons can be modified to increase their activity and mutagenic power in a variety of ways. Here we outline the advantages of using modified L1 retrotransposons for performing random mutagenesis in rodents and discuss several potential applications. © 2007 BioMed Central Ltd.
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