Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

被引：0

作者：

Wei-Yu Lin

Sarah E. Fordham

Eric Hungate

Nicola J. Sunter

Claire Elstob

Yaobo Xu

Catherine Park

Anne Quante

Konstantin Strauch

Christian Gieger

Andrew Skol

Thahira Rahman

Lara Sucheston-Campbell

Junke Wang

Theresa Hahn

Alyssa I. Clay-Gilmour

Gail L. Jones

Helen J. Marr

Graham H. Jackson

Tobias Menne

Mathew Collin

Adam Ivey

Robert K. Hills

Alan K. Burnett

Nigel H. Russell

Jude Fitzgibbon

Richard A. Larson

Michelle M. Le Beau

Wendy Stock

Olaf Heidenreich

Abrar Alharbi

David J. Allsup

Richard S. Houlston

Jean Norden

Anne M. Dickinson

Elisabeth Douglas

Clare Lendrem

Ann K. Daly

Louise Palm

Kim Piechocki

Sally Jeffries

Martin Bornhäuser

Christoph Röllig

Heidi Altmann

Leo Ruhnke

Desiree Kunadt

Lisa Wagenführ

Heather J. Cordell

Rebecca Darlay

Mette K. Andersen

机构：

[1] Newcastle University,Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences

[2] University of Chicago,Section of Pediatric Hematology and Oncology

[3] Helmholtz Zentrum München,Department of Medicine

[4] German Research Center for Environmental Health,Arnold School of Public Health, Department of Epidemiology & Biostatistics

[5] Ludwig-Maximilians-Universität München,Nuffield Department of Population Health

[6] Chair of Genetic Epidemiology,Translational and Clinical Research Institute, Faculty of Medical Sciences

[7] IBE,Department of Haematological Medicine

[8] Faculty of Medicine,Population Health Sciences Institute

[9] College of Pharmacy,Department of Clinical Genetics

[10] The Ohio State University,Institute of Hematology “L. and A. Seràgnoli”

[11] Roswell Park Cancer Institute,Hematology department

[12] University of South Carolina,Division of Hematology

[13] Department of Haematology,Department of Haematology

[14] Freeman Hospital,1st Department of Internal Medicine

[15] Newcastle upon Tyne Hospitals National Health Service Foundation Trust,3rd Department of Internal Medicine

[16] Department of Medical and Molecular Genetics,Department of Hematology and Oncology, Medical Faculty Mannheim

[17] King’s College Medical School,Department of Haematology

[18] University of Oxford,Helsinki University Hospital Comprehensive Cancer Center

[19] Paul O’Gorman Leukaemia Research Centre,Department of Laboratory Medicine

[20] University of Glasgow,HCEMM

[21] Department of Haematology,SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research

[22] Nottingham University Hospitals NHS Trust,undefined

[23] Barts Cancer Institute,undefined

[24] Queen Mary University of London,undefined

[25] Centre for Atherothrombosis and Metabolic Disease,undefined

[26] Hull York Medical School,undefined

[27] Division of Genetics and Epidemiology,undefined

[28] The Institute of Cancer Research,undefined

[29] Newcastle University,undefined

[30] West Midlands Regional Genetics Laboratory,undefined

[31] Birmingham Women’s Hospital,undefined

[32] The Rayne Institute,undefined

[33] King’s College London,undefined

[34] National Center for Tumor Diseases NCT,undefined

[35] Partner site Dresden,undefined

[36] Medizinische Klinik und Poliklinik I,undefined

[37] University Hospital Carl Gustav Carus Dresden,undefined

[38] Technical University of Dresden,undefined

[39] Newcastle University,undefined

[40] University Hospital Rigshospitalet,undefined

[41] University of Bologna,undefined

[42] IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”,undefined

[43] Hematology Service,undefined

[44] Hospital Universitario y Politécnico La Fe,undefined

[45] CIBERONC,undefined

[46] Instituto de Salud Carlos III,undefined

[47] Cote d’Azur University,undefined

[48] CHU of Nice,undefined

[49] Medical University of Graz,undefined

[50] Università di Roma Tor Vergata,undefined

来源：

Nature Communications | / 12卷

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摘要：

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).

引用

共 50 条

[1] Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
Lin, Wei-Yu
Fordham, Sarah E.
Hungate, Eric
Sunter, Nicola J.
Elstob, Claire
Xu, Yaobo
Park, Catherine
Quante, Anne
Strauch, Konstantin
Gieger, Christian
Skol, Andrew
Rahman, Thahira
Sucheston-Campbell, Lara
Wang, Junke
Hahn, Theresa
Clay-Gilmour, Alyssa I.
Jones, Gail L.
Marr, Helen J.
Jackson, Graham H.
Menne, Tobias
Collin, Mathew
Ivey, Adam
Hills, Robert K.
Burnett, Alan K.
Russell, Nigel H.
Fitzgibbon, Jude
Larson, Richard A.
Le Beau, Michelle M.
Stock, Wendy
Heidenreich, Olaf
Alharbi, Abrar
Allsup, David J.
Houlston, Richard S.
Norden, Jean
Dickinson, Anne M.
Douglas, Elisabeth
Lendrem, Clare
Daly, Ann K.
Palm, Louise
Piechocki, Kim
Jeffries, Sally
Bornhauser, Martin
Rollig, Christoph
Altmann, Heidi
Ruhnke, Leo
Kunadt, Desiree
Wagenfuhr, Lisa
Cordell, Heather J.
Darlay, Rebecca
Andersen, Mette K.
[J]. NATURE COMMUNICATIONS, 2021, 12 (01)
[2] Author Correction: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
Wei-Yu Lin
Sarah E. Fordham
Eric Hungate
Nicola J. Sunter
Claire Elstob
Yaobo Xu
Catherine Park
Anne Quante
Konstantin Strauch
Christian Gieger
Andrew Skol
Thahira Rahman
Lara Sucheston-Campbell
Junke Wang
Theresa Hahn
Alyssa I. Clay-Gilmour
Gail L. Jones
Helen J. Marr
Graham H. Jackson
Tobias Menne
Mathew Collin
Adam Ivey
Robert K. Hills
Alan K. Burnett
Nigel H. Russell
Jude Fitzgibbon
Richard A. Larson
Michelle M. Le Beau
Wendy Stock
Olaf Heidenreich
Abrar Alharbi
David J. Allsup
Richard S. Houlston
Jean Norden
Anne M. Dickinson
Elisabeth Douglas
Clare Lendrem
Ann K. Daly
Louise Palm
Kim Piechocki
Sally Jeffries
Martin Bornhäuser
Christoph Röllig
Heidi Altmann
Leo Ruhnke
Desiree Kunadt
Lisa Wagenführ
Heather J. Cordell
Rebecca Darlay
Mette K. Andersen
[J]. Nature Communications, 13
[3] Genome-wide association study identifies susceptibility loci for acute myeloid leukemia (vol 13, 2, 2022)
Lin, Wei-Yu
Fordham, Sarah E.
Hungate, Eric
Sunter, Nicola J.
Elstob, Claire
Xu, Yaobo
Park, Catherine
Quante, Anne
Strauch, Konstantin
Gieger, Christian
Skol, Andrew
Rahman, Thahira
Sucheston-Campbell, Lara
Wang, Junke
Hahn, Theresa
Clay-Gilmour, Alyssa I.
Jones, Gail L.
Marr, Helen J.
Jackson, Graham H.
Menne, Tobias
Collin, Mathew
Ivey, Adam
Hills, Robert K.
Burnett, Alan K.
Russell, Nigel H.
Fitzgibbon, Jude
Larson, Richard A.
Le Beau, Michelle M.
Stock, Wendy
Heidenreich, Olaf
Alharbi, Abrar
Allsup, David J.
Houlston, Richard S.
Norden, Jean
Dickinson, Anne M.
Douglas, Elisabeth
Lendrem, Clare
Daly, Ann K.
Palm, Louise
Piechocki, Kim
Jeffries, Sally
Bornhauser, Martin
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