Analytical results on the Beauchemin model of lymphocyte migration

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作者
Johannes Textor
Mathieu Sinn
Rob J de Boer
机构
[1] Utrecht University,Theoretical Biology & Bioinformatics
[2] University of Lübeck,Institute for Theoretical Computer Science
[3] IBM Research,undefined
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Random Walk; Cell Track; Convection Coefficient; Lymphocyte Migration; Functional Central Limit Theorem;
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摘要
The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provides a comprehensive overview of both existing and new analytical results on the Beauchemin model within a common mathematical framework. Specifically, we derive the motility coefficient, the mean square displacement, and the confinement ratio, and discuss four different methods for simulating biased migration of pre-defined speed. The results provide new insight into published studies and a reference point for future research based on this simple and popular lymphocyte migration model.
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