Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil

被引：0

作者：

Otavio T. Ranzani

Matt D. T. Hitchings

Rosana Leite de Melo

Giovanny V. A. de França

Cássia de Fátima R. Fernandes

Margaret L. Lind

Mario Sergio Scaramuzzini Torres

Daniel Henrique Tsuha

Leticia C. S. David

Rodrigo F. C. Said

Maria Almiron

Roberto D. de Oliveira

Derek A. T. Cummings

Natalie E. Dean

Jason R. Andrews

Albert I. Ko

Julio Croda

机构：

[1] Universitat Pompeu Fabra (UPF),Barcelona Institute for Global Health, ISGlobal

[2] Hospital das Clínicas,Pulmonary Division, Heart Institute

[3] Faculdade de Medicina,Department of Biostatistics, College of Public Health & Health Professions

[4] CIBER Epidemiología y Salud Pública (CIBERESP),Secretaria Extraordinária de Enfrentamento à Covid

[5] University of Florida,19

[6] Ministério da Saúde,Secretaria de Vigilância em Saúde

[7] Ministério da Saúde,Department of Epidemiology of Microbial Diseases

[8] Yale School of Public Health,Fiocruz Mato Grosso do Sul

[9] Municipal Health Secretary of Manaus,Department of Biology

[10] Fundação Oswaldo Cruz,Emerging Pathogens Institute

[11] Pan American Health Organization,Department of Biostatistics & Bioinformatics, Rollins School of Public Health

[12] State University of Mato Grosso do Sul,Division of Infectious Diseases and Geographic Medicine

[13] University of Florida,Instituto Gonçalo Moniz

[14] University of Florida,undefined

[15] Emory University,undefined

[16] Stanford University,undefined

[17] Fundação Oswaldo Cruz,undefined

[18] Universidade Federal de Mato Grosso do Sul,undefined

来源：

Nature Communications | / 13卷

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摘要：

The effectiveness of inactivated vaccines (VE) against symptomatic and severe COVID-19 caused by omicron is unknown. We conducted a nationwide, test-negative, case-control study to estimate VE for homologous and heterologous (BNT162b2) booster doses in adults who received two doses of CoronaVac in Brazil in the Omicron context. Analyzing 1,386,544 matched-pairs, VE against symptomatic disease was 8.6% (95% CI, 5.6–11.5) and 56.8% (95% CI, 56.3–57.3) in the period 8–59 days after receiving a homologous and heterologous booster, respectively. During the same interval, VE against severe Covid-19 was 73.6% (95% CI, 63.9–80.7) and 86.0% (95% CI, 84.5–87.4) after receiving a homologous and heterologous booster, respectively. Waning against severe Covid-19 after 120 days was only observed after a homologous booster. Heterologous booster might be preferable to individuals with completed primary series inactivated vaccine.

引用

共 50 条

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Ranzani, Otavio T.
Hitchings, Matt D. T.
de Melo, Rosana Leite
de Franca, Giovanny V. A.
Fernandes, Cassia de Fatima R.
Lind, Margaret L.
Torres, Mario Sergio Scaramuzzini
Tsuha, Daniel Henrique
David, Leticia C. S.
Said, Rodrigo F. C.
Almiron, Maria
de Oliveira, Roberto D.
Cummings, Derek A. T.
Dean, Natalie E.
Andrews, Jason R.
Ko, Albert I.
Croda, Julio
[J]. NATURE COMMUNICATIONS, 2022, 13 (01)
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