Ca2+ entry but not Ca2+ release is necessary for desensitization of ETA receptors in airway epithelial cells

被引：0

作者：

T. Meyer

M. Oles

L. Pott

机构：

[1] Institut für Physiologie,

[2] Ruhr-Universität Bochum,undefined

[3] D-44780 Bochum,undefined

[4] Germany,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2000年 / 361卷

关键词：

Epithelial cell Airway Endothelin-1 Desensitization Ca2+ signalling Fura;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Ca2+ transients evoked by endothelin-1 (ET-1) were measured in single cells of a human tracheal epithelial cell line using the fluorescent Ca2+ indicator fura-2. In line with a previous study, a single exposure to ET-1 (10 nM) for 10–20 s resulted in a long-lasting desensitization to a subsequent challenge by the peptide, without affecting sensitivity to agonists for other Ca2+-mobilizing receptors such as P2y or H1, respectively.

引用

页码：120 / 126

页数：6

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