P-Glycoprotein, not BCRP, Limits the Brain Uptake of [18F]Mefway in Rodent Brain

被引：0
|
作者：
Jae Yong Choi
Jin Sook Song
Minkyung Lee
Woon-Ki Cho
Jin Chung
Chul Hyoung Lyoo
Chul Hoon Kim
Jiae Park
Kyo Chul Lee
Kyeong Min Kim
Jee Hae Kang
Myung Ae Bae
Young Hoon Ryu
机构：
[1] Gangnam Severance Hospital,Department of Nuclear Medicine
[2] Yonsei University College of Medicine,Drug Discovery Platform Technology Group, Drug Discovery Division
[3] Korea Research Institute of Chemical Technology,Department of Nuclear Medicine
[4] Inha University College of Medicine,Department of Radiology
[5] Inha University Hospital,Department of Radiology
[6] Ewha Womans University School of Medicine,Department of Neurology
[7] Yonsei University College of Medicine,Department of Pharmacology
[8] Gangnam Severance Hospital,Brain Korea 21 PLUS Project for Medical Science
[9] Yonsei University College of Medicine,Molecular Imaging Research Center
[10] Yonsei University College of Medicine,Department of Chemistry and Biochemistry
[11] Yonsei University College of Medicine,undefined
[12] Korea Institute of Radiological and Medical Sciences,undefined
[13] Swarthmore College,undefined
来源：
Molecular Imaging and Biology | 2016年 / 18卷
关键词：
[; F]Mefway; P-glycoprotein; Breast cancer resistance protein; PET;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：267 / 273
页数：6
相关论文
共 50 条
  • [1] P-Glycoprotein, not BCRP, Limits the Brain Uptake of [18F]Mefway in Rodent Brain
    Choi, Jae Yong
    Song, Jin Sook
    Lee, Minkyung
    Cho, Woon-Ki
    Chung, Jin
    Lyoo, Chul Hyoung
    Kim, Chul Hoon
    Park, Jiae
    Lee, Kyo Chul
    Kim, Kyeong Min
    Kang, Jee Hae
    Bae, Myung Ae
    Ryu, Young Hoon
    MOLECULAR IMAGING AND BIOLOGY, 2016, 18 (02) : 267 - 273
  • [2] The Effect of P-glycoprotein and breast cancer resistance protein on the brain uptake of [18F]Mefway
    Choi, Jae Yong
    Song, Jin Sook
    Lyoo, Chul Hyoung
    Park, Ji Ae
    Lee, Jae-Hoon
    Lee, Kyochul
    Bae, Myung Ae
    Kim, Kyeong Min
    Ryu, Young Hoon
    JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (03)
  • [3] Influence of P-glycoprotein on brain uptake of [18F]MPPF in rats
    Passchier, J
    van Waarde, A
    Doze, P
    Elsinga, PH
    Vaalburg, W
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 407 (03) : 273 - 280
  • [4] [18F]FPEB is a substrate for Pgp and Bcrp in the rodent brain
    Choi, J.
    Jung, K.
    Oh, S.
    Kang, K.
    Han, S.
    Nam, K.
    Lee, K.
    Lee, Y.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (SUPPL 1) : S739 - S739
  • [5] Evaluation of the P-gp- and Bcrp-mediated brain penetration of [18F]FPEB in rodent brain
    Jung, K. H.
    Oh, S.
    Kang, K.
    Han, S.
    Nam, K.
    Choi, J.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 : 548 - 548
  • [6] Effects of P-gp and Bcrp as brain efflux transporters on the uptake of [18F]FPEB in the murine brain
    Jung, Ki-Hye
    Oh, Se Jong
    Kang, Kyung Jun
    Han, Sang Jin
    Nam, Kyung Rok
    Park, Ji Ae
    Lee, Kyo Chul
    Lee, Yong Jin
    Choi, Jae Yong
    SYNAPSE, 2019, 73 (11)
  • [7] [18F]FDG is not transported by P-glycoprotein and breast cancer resistance protein at the rodent blood-brain barrier
    Wanek, Thomas
    Traxl, Alexander
    Bankstahl, Jens P.
    Bankstahl, Marion
    Sauberer, Michael
    Langer, Oliver
    Kuntner, Claudia
    NUCLEAR MEDICINE AND BIOLOGY, 2015, 42 (07) : 585 - 589
  • [8] P-Glycoprotein Influence on the Brain Uptake of a 5-HT2A Ligand: [18F]MH.MZ
    Schmitt, Ulrich
    Leed, Dianne E.
    Herth, Matthias M.
    Piel, Markus
    Buchholz, Hans-Georg
    Roesch, Frank
    Hiemke, Christoph
    Lueddens, Hartmut
    Debus, Fabian
    NEUROPSYCHOBIOLOGY, 2011, 63 (03) : 183 - 190
  • [9] Rodent study of [18F]-mefway using microPET
    Saigal, Neil
    Faheem, S.
    Coleman, R.
    Constantinescu, C.
    Mukherjee, J.
    NEUROIMAGE, 2008, 41 : T165 - T165
  • [10] ROLE OF P-GLYCOPROTEIN AND BCRP IN THE DISTRIBUTION OF HUPERZINE A TO THE BRAIN IN MICE
    Wang, Meiyu
    Lu, Jia
    Xu, Yunting
    Wang, Yedong
    Li, Jiajun
    Zhang, Hongjian
    DRUG METABOLISM AND PHARMACOKINETICS, 2017, 32 (01) : S64 - S64
12345