Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

被引：0

作者：

Caroline Goujon

Olivier Moncorgé

Hélène Bauby

Tomas Doyle

Christopher C. Ward

Torsten Schaller

Stéphane Hué

Wendy S. Barclay

Reiner Schulz

Michael H. Malim

机构：

[1] King’s College London,Department of Infectious Diseases

[2] London SE1 9RT,Division of Infectious Diseases

[3] UK,Division of Infection and Immunity

[4] Section of Virology,Department of Medical and Molecular Genetics

[5] Imperial College London,undefined

[6] London W2 1PG,undefined

[7] UK,undefined

[8] Centre for Medical Molecular Virology,undefined

[9] University College London,undefined

[10] London WC1 6RT,undefined

[11] UK,undefined

[12] King’s College London,undefined

[13] London SE1 9RT,undefined

[14] UK,undefined

来源：

Nature | 2013年 / 502卷

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D O I：

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学科分类号：

摘要：

Here, a protein known as MX2 is shown to be a major effector of interferon-α-mediated resistance to HIV-1 infection: susceptibility of the HIV-1 virus to inhibition by MX2 is dictated by the Capsid region of the viral Gag protein, and inhibition occurs at a late post-entry step of infection.

引用

页码：559 / 562

页数：3

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