1-(Pyrimidin-4-yl)pyrazol-5(4H)-one derivatives: I. Synthesis of 3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-pyrazol-5-ol and specificity of its Knoevenagel reaction

被引：0

作者：

A. V. Erkin

V. I. Krutikov

机构：

[1] St. Petersburg State Institute of Technology,

来源：

Russian Journal of General Chemistry | 2011年 / 81卷

关键词：

Pyrazole; Aromatic Aldehyde; Ethyl Acetoacetate; Hydrazono; Knoevenagel Reaction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3-Methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1H-pyrazol-5-ol available via cyclocondensation of 6-methyl-2-methylsulfanylpyrimidin-4-ylhydrazine with ethyl acetoacetate reacted with aromatic aldehydes to give two kinds of products, 4-arylmethylidene-5-oxo-4,5-dihydropyrazole and arylbis(5-hydroxypyrazol-4-yl)methane derivatives, depending on the substituent in the aromatic aldehyde.

引用

页码：392 / 396

页数：4

共 50 条

[1] 1-(Pyrimidin-4-yl)pyrazol-5(4H)-one derivatives: I. Synthesis of 3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-pyrazol-5-ol and specificity of its Knoevenagel reaction
Erkin, A. V.
Krutikov, V. I.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2011, 81 (02) : 392 - 396
[2] 1-(Pyrimidin-4-yl)pyrazol-5(4H)-one derivatives: II. Electrophilic substitution in 5-hydroxy-3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1H-pyrazole
Erkin, A. V.
Krutikov, V. I.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2011, 81 (08) : 1705 - 1710
[3] 1-(Pyrimidin-4-yl)pyrazol-5(4H)-one derivatives: II. Electrophilic substitution in 5-hydroxy-3-methyl-1-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1H-pyrazole
A. V. Erkin
V. I. Krutikov
Russian Journal of General Chemistry, 2011, 81 : 1705 - 1710
[4] 1-(Pyrimidin-4-yl)pyrazol-5(4H)-one Derivatives: III. The Medium Properties Effect on the Position and Mobility of the Labile Proton of 5-Hydroxy-3-methyl-1-(6-methyl-2-methylthio-4-yl)pyrazole
Erkin, A. V.
Krutikov, V. I.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2011, 81 (09) : 1889 - 1892
[5] 1-(Pyrimidin-4-yl)pyrazol-5(4H)-one derivatives: III. The medium properties effect on the position and mobility of the labile proton of 5-hydroxy-3-methyl-1-(6-methyl-2-methylthio-4-yl)pyrazole
A. V. Erkin
V. I. Krutikov
Russian Journal of General Chemistry, 2011, 81 : 1889 - 1892
[6] Synthesis and tuberculocidic activity of some 4-arylaminomethylene-3-methyl-1-(pyrimidin-2-yl)pyrazol-5(4H)-ones
A. V. Erkin
V. I. Krutikov
A. A. Ivanov
Russian Journal of General Chemistry, 2012, 82 : 153 - 156
[7] Synthesis and tuberculocidic activity of some 4-arylaminomethylene-3-methyl-1-(pyrimidin-2-yl)pyrazol-5(4H)-ones
Erkin, A. V.
Krutikov, V. I.
Ivanov, A. A.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2012, 82 (01) : 153 - 156
[8] A Domino Reaction of 3-Methyl-1-[6-Methyl-2-(Methylsulfanyl)Pyrimidin-4-yl]-4-[(Phenyl-Imino)Methyl]-1H-Pyrazol-5-ol with Hetero-Cyclic ch Acids
Erkin, A. V.
Ramsh, S. M.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2014, 50 (08) : 1102 - 1106
[9] A Domino Reaction of 3-Methyl-1-[6-Methyl-2-(Methylsulfanyl)Pyrimidin-4-yl]-4-[(Phenyl-Imino)Methyl]-1H-Pyrazol-5-ol with Hetero-Cyclic ch Acids
A. V. Erkin
S. M. Ramsh
Chemistry of Heterocyclic Compounds, 2014, 50 : 1102 - 1106
[10] Racemic N-methyl-4-[2-(methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-3-yl)-1H-pyrazol-5-amine
Liu, Zhengyu
Liu, Kevin K. -C.
Rheingold, Arnold L.
DiPasquale, Antonio
Yanovsky, Alex
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O1089 - U2639

← 1 2 3 4 5 →