Synthesis and aminomethylation of regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones

被引：0
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作者：
Antonina V. Popova
Svitlana P. Bondarenko
Mykhaylo S. Frasinyuk
机构：
[1] National Academy of Sciences of Ukraine,V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry
[2] National University of Food Technologies,undefined
来源：
Chemistry of Heterocyclic Compounds | 2018年 / 54卷
关键词：
benzofuran-3(2; )-one; 4-hydroxy-6-methylaurone; 6-hydroxy-4-methylaurone; aminomethylation; Mannich bases;
D O I：
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学科分类号：
摘要：
The regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones were synthesized. Aminomethylation by the action of aminals of secondary amines was investigated. It was shown that the reaction proceeds selectively with the formation of 7-aminomethyl-6-hydroxy-4-methyl- and 5-aminomethyl-4-hydroxy-6-methylaurones, respectively. The use of an excess of the aminals allows to obtain 5,7-bis(aminomethyl) derivatives of 6-hydroxy-4-methylaurones.
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页码：832 / 839
页数：7
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