The gut-liver axis in hepatobiliary diseases

被引：0
|
作者：
Masataka Ichikawa
Haruka Okada
Nobuhiro Nakamoto
Nobuhito Taniki
Po-Sung Chu
Takanori Kanai
机构：
[1] Keio University School of Medicine,Division of Gastroenterology and Hepatology, Department of Internal Medicine
来源：
Inflammation and Regeneration | / 44卷
关键词：
Intestinal bacteria; Gut-liver axis; Leaky gut; Primary sclerosing cholangitis; Fecal microbiota transplantation; Bacteriophage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases. The mechanisms behind the changes in intestinal bacteria in various hepatobiliary diseases include the abnormal composition of intestinal bacteria, weakening of the intestinal barrier, and bacterial translocation outside the intestinal tract, along with their metabolites, but many aspects remain unresolved. Further research employing clinical studies and animal models is expected to clarify the direct relationship between intestinal bacteria and hepatobiliary diseases and to validate the utility of intestinal bacteria as a diagnostic biomarker and potential therapeutic target. This review summarizes the involvement of the microbiota in the pathogenesis of hepatobiliary diseases via the gut-liver axis.
引用
收藏
相关论文
共 50 条
  • [1] The gut-liver axis in hepatobiliary diseases
    Ichikawa, Masataka
    Okada, Haruka
    Nakamoto, Nobuhiro
    Taniki, Nobuhito
    Chu, Po-Sung
    Kanai, Takanori
    [J]. INFLAMMATION AND REGENERATION, 2024, 44 (01)
  • [2] The Gut-Liver Axis in Cholestatic Liver Diseases
    Blesl, Andreas
    Stadlbauer, Vanessa
    [J]. NUTRIENTS, 2021, 13 (03) : 1 - 32
  • [3] Fat, cancer, the gut-liver axis and rare liver diseases
    Berenguer, Marina
    [J]. JHEP REPORTS, 2020, 2 (06)
  • [4] The gut-liver axis
    Visschers, Ruben G. J.
    Luyer, Misha D.
    Schaap, Frank G.
    Damink, Steven W. M. Olde
    Soeters, Peter B.
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2013, 16 (05): : 576 - 581
  • [5] Gut-liver axis
    Zeuzem, S
    [J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2000, 15 (02) : 59 - 82
  • [6] Gut-liver axis
    S. Zeuzem
    [J]. International Journal of Colorectal Disease, 2000, 15 : 59 - 82
  • [7] The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases
    Yang, Xinyu
    Lu, Di
    Zhuo, Jianyong
    Lin, Zuyuan
    Yang, Modan
    Xu, Xiao
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (13): : 2357 - 2366
  • [8] Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases
    Bruneau, Alix
    Hundertmark, Jana
    Guillot, Adrien
    Tacke, Frank
    [J]. FRONTIERS IN MEDICINE, 2021, 8
  • [9] HEPATOBILIARY PHENOTYPE OF INDIVIDUALS WITH CHRONIC INTESTINAL DISORDERS - THE GUT-LIVER AXIS IN UKBIOBANK
    Voss, Jessica
    Schneider, Carolin Victoria
    Kleinjans, Moritz
    Bruns, Tony
    Trautwein, Christian
    Strnad, Pavel
    [J]. HEPATOLOGY, 2021, 74 : 358A - 358A
  • [10] Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature
    Milosevic, Ivana
    Vujovic, Ankica
    Barac, Aleksandra
    Djelic, Marina
    Korac, Milos
    Spurnic, Aleksandra Radovanovic
    Gmizic, Ivana
    Stevanovic, Olja
    Djordjevic, Vladimir
    Lekic, Nebojsa
    Russo, Edda
    Amedei, Amedeo
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (02):
12345