To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

被引：0

作者：

Marieke J. H. Begemann

Ilse A. Thompson

Wim Veling

Shiral S. Gangadin

Chris N. W. Geraets

Erna van ‘t Hag

Sanne J. Müller-Kuperus

Priscilla P. Oomen

Alban E. Voppel

Mark van der Gaag

Martijn J. Kikkert

Jim Van Os

H. Filip E. Smit

Rikus H. Knegtering

Sybren Wiersma

Luyken H. Stouten

Harm J. Gijsman

Lex Wunderink

Anton B. P. Staring

Selene R. T. Veerman

Amrita G. S. Mahabir

Jörg Kurkamp

Gerdina H. M. Pijnenborg

Natalie D. Veen

Machteld Marcelis

Koen P. Grootens

Gunnar Faber

Nico J. van Beveren

Agaath Been

Truus van den Brink

Maarten Bak

Therese A. M. J. van Amelsvoort

Andrea Ruissen

Christine Blanke

Karin Groen

Lieuwe de Haan

Iris E. C. Sommer

机构：

[1] University of Groningen,Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences

[2] University Medical Center Groningen (UMCG),Department of Psychiatry

[3] University of Groningen,Department of Psychiatry, UMC Utrecht Brain Center

[4] University Medical Center Groningen,Department of Clinical Psychology

[5] University Medical Center Utrecht,Department of Research

[6] Parnassia Psychiatric Institute,Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON

[7] VU University,Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience

[8] Arkin Mental Health Care,Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute

[9] Maastricht University Medical Center,Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute

[10] King’s College London,Centre of Economic Evaluation

[11] VU University Medical Center,Lentis Research

[12] VU University Medical Center,Rob Giel Research Center

[13] Trimbos Institute (Netherlands Institute of Mental Health),Early Intervention Psychosis Team

[14] Lentis Psychiatric Institute,Centre for Early Psychosis

[15] University of Groningen,Program for Psychosis & Severe Mental Illness

[16] University Medical Center Groningen,Department of Education and Research

[17] GGZ inGeest Specialized Mental Health Care,Department ABC

[18] Parnassia Psychiatric Institute,Community Mental Health

[19] Pro Persona Mental Health,Early Psychosis Team

[20] Friesland Mental Health Care Services,Center for Youth with Psychosis

[21] Altrecht Psychiatric Institute,Department of Psychotic Disorders

[22] Mental Health Service Noord-Holland Noord,GGZ Delfland

[23] GGNet,Department of Neuroscience

[24] Mediant ABC Twente,Department of Psychiatry

[25] GGZ-Drenthe,Center for Developmental Disorders

[26] Delfland Institute for Mental Health Care,Early Intervention Team

[27] Institute for Mental Health Care Eindhoven (GGzE),Department of Early Psychosis

[28] Reinier van Arkel Institute for Mental Health Care,undefined

[29] Radboud University Medical Centre,undefined

[30] Yulius,undefined

[31] Mental Health Institute,undefined

[32] Antes Center for Mental Health Care,undefined

[33] Erasmus MC,undefined

[34] Erasmus MC,undefined

[35] Dimence Institute for Mental Health,undefined

[36] GGZ Centraal,undefined

[37] Mondriaan Mental Health Care,undefined

[38] Emergis,undefined

[39] Kenniscentrum,undefined

[40] Anoiksis,undefined

[41] University Medical Center Utrecht,undefined

[42] MIND Ypsilon,undefined

[43] Organization of Relatives and Carers of People with a Vulnerability to Psychosis,undefined

[44] Amsterdam UMC,undefined

[45] Academic Medical Center,undefined

来源：

Trials | / 21卷

关键词：

Antipsychotic medication, first episode psychosis; Maintenance; Treatment; Discontinuation; Tapering, global functioning; Randomized controlled trial;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 43 条

[1] To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial
Begemann, Marieke J. H.
Thompson, Ilse A.
Veling, Wim
Gangadin, Shiral S.
Geraets, Chris N. W.
van 't Hag, Erna
Mueller-Kuperus, Sanne J.
Oomen, Priscilla P.
Voppel, Alban E.
van der Gaag, Mark
Kikkert, Martijn J.
Van Os, Jim
Smit, H. Filip E.
Knegtering, Rikus H.
Wiersma, Sybren
Stouten, Luyken H.
Gijsman, Harm J.
Wunderink, Lex
Staring, Anton B. P.
Veerman, Selene R. T.
Mahabir, Amrita G. S.
Kurkamp, Jorg
Pijnenborg, Gerdina H. M.
Veen, Natalie D.
Marcelis, Machteld
Grootens, Koen P.
Faber, Gunnar
van Beveren, Nico J.
Been, Agaath
van den Brink, Truus
Bak, Maarten
van Amelsvoort, Therese A. M. J.
Ruissen, Andrea
Blanke, Christine
Groen, Karin
de Haan, Lieuwe
Sommer, Iris E. C.
[J]. TRIALS, 2020, 21 (01)
[2] POSTER PRESENTATION: HAMLETT: HANDLING ANTIPSYCHOTIC MEDICATION, A LONGTERM EVALUATION OF TARGETED TREATMENT A PRAGMATIC SINGLE-BLIND RANDOMISED CONTROLLED TRIAL OF CONTINUATION VERSUS DISCONTINUATION OF PSYCHOTIC MEDICATION
van't Hag, Erna
[J]. SCHIZOPHRENIA BULLETIN, 2020, 46 : S246 - S246
[3] Discontinuation Versus Maintenance Therapy with Antipsychotic Medication in Schizophrenia - Tailor: A Randomized Controlled Trial
Sturup, Anne Emilie
Jensen, Heidi
Dolmer, Signe
Albert, Nikolai
Birk, Merete
Hjorthoj, Carsten
Eplov, Lene Falgaard
Ebdrup, Bjorn
Wunderink, Lex
Mors, Ole
Nordentoft, Merete
[J]. EARLY INTERVENTION IN PSYCHIATRY, 2018, 12 : 141 - 141
[4] Discontinuation versus maintenance therapy with antipsychotic medication in schizophrenia - Tailor: A randomized controlled trial
Sturup, Anne Emilie
Jensen, Heidi
Dolmer, Signe
Birk, Merete
Ebdrup, Bjorn
Hjorthoj, Carsten
Eplov, Lene Falgaard
Wunderink, Lex
Mors, Ole
Nordentoft, Merete
[J]. EARLY INTERVENTION IN PSYCHIATRY, 2016, 10 : 151 - 151
[5] Model-Guided Antipsychotic Dose Reduction in Schizophrenia A Pilot, Single-Blind Randomized Controlled Trial
Ozawa, Chisa
Bies, Robert R.
Pillai, Nikhil
Suzuki, Takefumi
Mimura, Masaru
Uchida, Hiroyuki
[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2019, 39 (04) : 329 - 335
[6] Isolating the impact of antipsychotic medication on metabolic health: Secondary analysis of a randomized controlled trial of antipsychotic medication versus placebo in antipsychotic medication naive first-episode psychosis (the STAGES study)
O'Donoghue, Brian
Allott, Kelly
Harrigan, Susy
Scalzo, Franco
Ward, Janine
Mallawaarachchi, Sumudu
Whitson, Sarah
Baldwin, Lara
Graham, Jessica
Mullen, Edward
MacNeil, Craig
Alexander, Dylan
Wood, Stephen J.
Berk, Michael
Alvarez-Jimenez, Mario
Thompson, Andrew
Fornito, Alex
Yuen, Hok Pan
Nelson, Barnaby
Francey, Shona M.
McGorry, Patrick
[J]. EARLY INTERVENTION IN PSYCHIATRY, 2023, 17 (06) : 597 - 607
[7] Can antipsychotic dose reduction lead to better functional recovery in first-episode psychosis? A randomized controlled-trial of antipsychotic dose reduction. The reduce trial: Study protocol
Weller, Amber
Gleeson, John
Alvarez-Jimenez, Mario
McGorry, Patrick
Nelson, Barnaby
Allott, Kelly
Bendall, Sarah
Bartholomeusz, Cali
Koval, Peter
Harrigan, Susy
O'Donoghue, Brian
Fornito, Alex
Pantelis, Christos
Amminger, G. Paul
Ratheesh, Aswin
Polari, Andrea
Wood, Stephen J.
van der El, Kristi
Ellinghaus, Carli
Gates, Jesse
O'Connell, Jessica
Mueller, Marianne
Wunderink, Lex
Killackey, Eoin
[J]. EARLY INTERVENTION IN PSYCHIATRY, 2019, 13 (06) : 1345 - 1356
[8] RANITIDINE VERSUS ANTICHOLINERGIC ANTACID FOR DUODENAL-ULCER - A RANDOMIZED, ENDOSCOPICALLY CONTROLLED, SINGLE-BLIND MULTICENTER TRIAL
MIETTINEN, P
ANTTONEN, V
AUKEE, S
HUTTUNEN, R
LAHTINEN, J
POIKOLAINEN, E
PAAKKONEN, M
TAMMELA, T
[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1985, 20 (06) : 701 - 705
[9] Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial
Chen, Eric Y. H.
Hui, Christy L. M.
Lam, May M. L.
Chiu, Cindy P. Y.
Law, C. W.
Chung, Dicky W. S.
Tso, Steve
Pang, Edwin P. F.
Chan, K. T.
Wong, Y. C.
Mo, Flora Y. M.
Chan, Kathy P. M.
Yao, T. J.
Hung, S. F.
Honer, William G.
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2010, 341
[10] RANDOMIZED CONTROLLED TRIAL OF OLANZAPINE OR CHLORPROMAZINE AS ADDITION TO LITHIUM IN THE TREATMENT OF A FIRST MANIC EPISODE WITH PSYCHOTIC FEATURES: AN 8-WEEK, FLEXIBLE DOSE, SINGLE-BLIND TRIAL
Conus, Philippe
Cotton, Sue
Kader, Linda
Macneil, Craig A.
Hasty, Melissa
Hallam, Karen T.
McGorry, Pat D.
Berk, Michael
[J]. BIPOLAR DISORDERS, 2009, 11 (07) : 779 - 779

← 1 2 3 4 5 →