Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

被引：0
|
作者：
J E Noll
S A Williams
L E Purton
A C W Zannettino
机构：
[1] Myeloma Research Laboratory,Department of Haematology
[2] Bone and Cancer Research Laboratories,Department of Medicine
[3] Centre for Cancer Biology,undefined
[4] Stem Cell Regulation Unit,undefined
[5] St Vincent’s Institute,undefined
[6] St Vincent’s Hospital,undefined
[7] The University of Melbourne,undefined
[8] Centre for Personalised Cancer Medicine and Centre for Stem Cell Research,undefined
[9] Faculty of Health Sciences,undefined
[10] University of Adelaide,undefined
来源：
Blood Cancer Journal | 2012年 / 2卷
关键词：
myeloma; niche; bone microenvironment; haematopoietic stem cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the adult mammal, normal haematopoiesis occurs predominantly in the bone marrow, where primitive haematopoietic stem cells (HSC) and their progeny reside in specialised microenvironments. The bone marrow microenvironment contains specific anatomical areas (termed niches) that are highly specialised for the development of certain blood cell types, for example HSCs. The HSC niche provides important cell–cell interactions and signalling molecules that regulate HSC self-renewal and differentiation processes. These same signals and interactions are also important in the progression of haematological malignancies, such as multiple myeloma (MM). This review provides an overview of the bone marrow microenvironment and its involvement in normal, physiological HSC maintenance and plasma cell growth throughout MM disease progression.
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页码：e91 / e91
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