DNA interstrand cross-link repair requires replication-fork convergence

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作者
Jieqiong Zhang
James M Dewar
Magda Budzowska
Anna Motnenko
Martin A Cohn
Johannes C Walter
机构
[1] Harvard Medical School,Department of Biological Chemistry and Molecular Pharmacology
[2] University of Oxford,Department of Biochemistry
[3] Howard Hughes Medical Institute,Department of Biological Chemistry and Molecular Pharmacology
[4] Harvard Medical School,undefined
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摘要
New biochemical analyses in Xenopus cell-free extracts show that two replication forks must converge on a DNA interstrand cross-link (ICL) to permit translesion synthesis and repair.
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页码:242 / 247
页数:5
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