Neurite Outgrowth is Dependent on the Association of c-Src and Lipid Rafts

被引：0
|
作者：
Hui Zhao
Xiaoding Cao
Gencheng Wu
Horace H. Loh
Ping-Yee Law
机构：
[1] Fudan University,Department of Integrative Medicine and Neurobiology, National Key Lab of Medical Neurobiology, Institutes of Brain Research Sciences, Shanghai Medical College
[2] University of Minnesota,Department of Pharmacology, Medical School
来源：
Neurochemical Research | 2009年 / 34卷
关键词：
Neurite outgrowth, c-Src; Src phosphorylation; Lipid rafts;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Regulation of neurite outgrowth is an important aspect not only for proper development of the nervous system but also for tissue regeneration after nerve injury and the treatment of neuropathological conditions. Here, we report that neurite outgrowth in cortical neuron and neuro 2A (N2A) cell was dependent on intact lipid rafts, as well as the enhanced localization of c-Src in the lipid rafts. Src inhibition or lipid rafts disruption could specifically block c-Src phosphorylation profile, pY416 Src increase and pY529 Src decrease, they also resulted in pY529 Src and c-terminal Src kinase (Csk) partition out of lipid rafts. Thus, we concluded that c-Src signal cascades within the lipid rafts is crucial for efficient neurite outgrowth.
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页码：2197 / 2205
页数：8
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